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Synthesis and Evaluation of Prodrugs of α-Carboxy Nucleoside Phosphonates

[Image: see text] A range of lipophilic prodrugs of α-carboxy nucleoside phosphonates, potent inhibitors of HIV-1 reverse transcriptase without requiring prior phosphorylation, were synthesized to evaluate their in vivo potency against HIV in cell culture. A series of prodrug derivatives bearing a f...

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Detalles Bibliográficos
Autores principales:	Ford, Alan, Mullins, Nicholas D., Balzarini, Jan, Maguire, Anita R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639015/ https://www.ncbi.nlm.nih.gov/pubmed/36283025 http://dx.doi.org/10.1021/acs.joc.2c02135

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