Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients

Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for...

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Autores principales: Peterlin, Pierre, Debord, Camille, Eveillard, Marion, Garnier, Alice, Le Bourgeois, Amandine, Guillaume, Thierry, Jullien, Maxime, Béné, Marie C., Chevallier, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639029/
https://www.ncbi.nlm.nih.gov/pubmed/36226545
http://dx.doi.org/10.1111/jcmm.17576
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author Peterlin, Pierre
Debord, Camille
Eveillard, Marion
Garnier, Alice
Le Bourgeois, Amandine
Guillaume, Thierry
Jullien, Maxime
Béné, Marie C.
Chevallier, Patrice
author_facet Peterlin, Pierre
Debord, Camille
Eveillard, Marion
Garnier, Alice
Le Bourgeois, Amandine
Guillaume, Thierry
Jullien, Maxime
Béné, Marie C.
Chevallier, Patrice
author_sort Peterlin, Pierre
collection PubMed
description Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for first‐line intensive chemotherapy, were included with the aim to study the influence on long‐term outcomes of peripheral blood (PB) levels of monocytic (M) MDSC (M‐MDSC) assessed by flow cytometry. A percentage of peripheral M‐MDSC higher than 0.55% of leukocytes at diagnosis and a decrease of M‐MDSC% after induction came out both as independent negative prognostic factors for leukaemia‐free and overall survival.
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spelling pubmed-96390292022-11-14 Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients Peterlin, Pierre Debord, Camille Eveillard, Marion Garnier, Alice Le Bourgeois, Amandine Guillaume, Thierry Jullien, Maxime Béné, Marie C. Chevallier, Patrice J Cell Mol Med Original Articles Myeloid Derived Suppressive Cells (MDSC) are capable to suppress innate and adaptive immune responses, thus favouring solid cancer progression. However, little is known about the role of MDSC in acute myeloid leukaemia (AML). In this monocentric prospective study, 73 adult AML patients, eligible for first‐line intensive chemotherapy, were included with the aim to study the influence on long‐term outcomes of peripheral blood (PB) levels of monocytic (M) MDSC (M‐MDSC) assessed by flow cytometry. A percentage of peripheral M‐MDSC higher than 0.55% of leukocytes at diagnosis and a decrease of M‐MDSC% after induction came out both as independent negative prognostic factors for leukaemia‐free and overall survival. John Wiley and Sons Inc. 2022-10-13 2022-11 /pmc/articles/PMC9639029/ /pubmed/36226545 http://dx.doi.org/10.1111/jcmm.17576 Text en © 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Peterlin, Pierre
Debord, Camille
Eveillard, Marion
Garnier, Alice
Le Bourgeois, Amandine
Guillaume, Thierry
Jullien, Maxime
Béné, Marie C.
Chevallier, Patrice
Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
title Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
title_full Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
title_fullStr Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
title_full_unstemmed Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
title_short Peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in AML patients
title_sort peripheral levels of monocytic myeloid‐derived suppressive cells before and after first induction predict relapse and survivals in aml patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639029/
https://www.ncbi.nlm.nih.gov/pubmed/36226545
http://dx.doi.org/10.1111/jcmm.17576
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