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Larotrectinib induces autophagic cell death through AMPK/mTOR signalling in colon cancer
Larotrectinib (Lar) is a highly selective and potent small‐molecule inhibitor used in patients with tropomyosin receptor kinase (TRK) fusion‐positive cancers, including colon cancer. However, the underlying molecular mechanisms specifically in patients with colon cancer have not yet been explored. O...
Autores principales: | Kong, Wencheng, Zhu, Hangzhang, Zheng, Sixing, Yin, Guang, Yu, Panpan, Shan, Yuqiang, Liu, Xinchun, Ying, Rongchao, Zhu, Hong, Ma, Shenglin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639042/ https://www.ncbi.nlm.nih.gov/pubmed/36251949 http://dx.doi.org/10.1111/jcmm.17530 |
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