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Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study

INTRODUCTION: The diagnosis, progression or recurrence of cancer is often highly traumatic for family caregivers (FCs), but systematic assessments of distress and approaches for its prevention and treatment are lacking. Acute leukaemia (AL) is a life-threatening cancer of the blood, which most often...

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Autores principales: Jibb, Lindsay A, Nanos, Stephanie M, Alexander, Sarah, Malfitano, Carmine, Rydall, Anne, Gupta, Sumit, Schimmer, Aaron D, Zimmermann, Camilla, Hales, Sarah, Nissim, Rinat, Marmar, Charles, Schultebraucks, Katharina, Mah, Kenneth, Rodin, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639100/
https://www.ncbi.nlm.nih.gov/pubmed/36332954
http://dx.doi.org/10.1136/bmjopen-2022-065422
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author Jibb, Lindsay A
Nanos, Stephanie M
Alexander, Sarah
Malfitano, Carmine
Rydall, Anne
Gupta, Sumit
Schimmer, Aaron D
Zimmermann, Camilla
Hales, Sarah
Nissim, Rinat
Marmar, Charles
Schultebraucks, Katharina
Mah, Kenneth
Rodin, Gary
author_facet Jibb, Lindsay A
Nanos, Stephanie M
Alexander, Sarah
Malfitano, Carmine
Rydall, Anne
Gupta, Sumit
Schimmer, Aaron D
Zimmermann, Camilla
Hales, Sarah
Nissim, Rinat
Marmar, Charles
Schultebraucks, Katharina
Mah, Kenneth
Rodin, Gary
author_sort Jibb, Lindsay A
collection PubMed
description INTRODUCTION: The diagnosis, progression or recurrence of cancer is often highly traumatic for family caregivers (FCs), but systematic assessments of distress and approaches for its prevention and treatment are lacking. Acute leukaemia (AL) is a life-threatening cancer of the blood, which most often presents acutely, requires intensive treatment and is associated with severe physical symptoms. Consequently, traumatic stress may be common in the FCs of patients with AL. We aim to determine the prevalence, severity, longitudinal course and predictors of traumatic stress symptoms in FCs of patients with AL in the first year after diagnosis, and to understand their lived experience of traumatic stress and perceived support needs. METHODS AND ANALYSIS: This two-site longitudinal, observational, mixed methods study will recruit 223 adult FCs of paediatric or adult patients newly diagnosed with AL from two tertiary care centres. Quantitative data will be collected from self-report questionnaires at enrolment, and 1, 3, 6, 9 and 12 months after admission to hospital for initial treatment. Quantitative data will be analysed using descriptive and machine learning approaches and a multilevel modelling (MLM) approach will be used to confirm machine learning findings. Semi-structured qualitative interviews will be conducted at 3, 6 and 12 months and analysed using a grounded theory approach. ETHICS AND DISSEMINATION: This study is funded by the Canadian Institutes of Health Research (CIHR number PJT 173255) and has received ethical approval from the Ontario Cancer Research Ethics Board (CTO Project ID: 2104). The data generated have the potential to inform the development of targeted psychosocial interventions for traumatic stress, which is a public health priority for high-risk populations such as FCs of patients with haematological malignancies. An integrated and end-of-study knowledge translation strategy that involves FCs and other stakeholders will be used to interpret and disseminate study results.
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spelling pubmed-96391002022-11-08 Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study Jibb, Lindsay A Nanos, Stephanie M Alexander, Sarah Malfitano, Carmine Rydall, Anne Gupta, Sumit Schimmer, Aaron D Zimmermann, Camilla Hales, Sarah Nissim, Rinat Marmar, Charles Schultebraucks, Katharina Mah, Kenneth Rodin, Gary BMJ Open Oncology INTRODUCTION: The diagnosis, progression or recurrence of cancer is often highly traumatic for family caregivers (FCs), but systematic assessments of distress and approaches for its prevention and treatment are lacking. Acute leukaemia (AL) is a life-threatening cancer of the blood, which most often presents acutely, requires intensive treatment and is associated with severe physical symptoms. Consequently, traumatic stress may be common in the FCs of patients with AL. We aim to determine the prevalence, severity, longitudinal course and predictors of traumatic stress symptoms in FCs of patients with AL in the first year after diagnosis, and to understand their lived experience of traumatic stress and perceived support needs. METHODS AND ANALYSIS: This two-site longitudinal, observational, mixed methods study will recruit 223 adult FCs of paediatric or adult patients newly diagnosed with AL from two tertiary care centres. Quantitative data will be collected from self-report questionnaires at enrolment, and 1, 3, 6, 9 and 12 months after admission to hospital for initial treatment. Quantitative data will be analysed using descriptive and machine learning approaches and a multilevel modelling (MLM) approach will be used to confirm machine learning findings. Semi-structured qualitative interviews will be conducted at 3, 6 and 12 months and analysed using a grounded theory approach. ETHICS AND DISSEMINATION: This study is funded by the Canadian Institutes of Health Research (CIHR number PJT 173255) and has received ethical approval from the Ontario Cancer Research Ethics Board (CTO Project ID: 2104). The data generated have the potential to inform the development of targeted psychosocial interventions for traumatic stress, which is a public health priority for high-risk populations such as FCs of patients with haematological malignancies. An integrated and end-of-study knowledge translation strategy that involves FCs and other stakeholders will be used to interpret and disseminate study results. BMJ Publishing Group 2022-11-04 /pmc/articles/PMC9639100/ /pubmed/36332954 http://dx.doi.org/10.1136/bmjopen-2022-065422 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Oncology
Jibb, Lindsay A
Nanos, Stephanie M
Alexander, Sarah
Malfitano, Carmine
Rydall, Anne
Gupta, Sumit
Schimmer, Aaron D
Zimmermann, Camilla
Hales, Sarah
Nissim, Rinat
Marmar, Charles
Schultebraucks, Katharina
Mah, Kenneth
Rodin, Gary
Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
title Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
title_full Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
title_fullStr Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
title_full_unstemmed Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
title_short Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
title_sort traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639100/
https://www.ncbi.nlm.nih.gov/pubmed/36332954
http://dx.doi.org/10.1136/bmjopen-2022-065422
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