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Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites

OBJECTIVES: Our primary objective was to establish preliminary normal reference curves for ultrasound–dermal thickness and skin stiffness in the 17 Rodnan skin sites, considering the effect of gender and age on these measures. As an exploratory objective, we investigated the effect of body mass inde...

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Autores principales: Santiago, Tânia, Santos, Eduardo José Ferreira, Luis, Mariana, Gaspar, Catarina, Lima, João, Caramelo, Francisco, da Silva, Jose Antonio Pereira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639157/
https://www.ncbi.nlm.nih.gov/pubmed/36323485
http://dx.doi.org/10.1136/rmdopen-2022-002577
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author Santiago, Tânia
Santos, Eduardo José Ferreira
Luis, Mariana
Gaspar, Catarina
Lima, João
Caramelo, Francisco
da Silva, Jose Antonio Pereira
author_facet Santiago, Tânia
Santos, Eduardo José Ferreira
Luis, Mariana
Gaspar, Catarina
Lima, João
Caramelo, Francisco
da Silva, Jose Antonio Pereira
author_sort Santiago, Tânia
collection PubMed
description OBJECTIVES: Our primary objective was to establish preliminary normal reference curves for ultrasound–dermal thickness and skin stiffness in the 17 Rodnan skin sites, considering the effect of gender and age on these measures. As an exploratory objective, we investigated the effect of body mass index and the menopause on skin ultrasound measures. METHODS: A cross-sectional study was conducted involving 140 healthy volunteers, aged 20–79 years. Recruitment was stratified by gender and age (10-year categories). Ultrasound–dermal thickness and skin stiffness were assessed by high-frequency ultrasound and shear-wave elastography, respectively, at the 17 Rodnan skin sites. Outcomes were evaluated through a mixed linear model, univariate and multivariate regressions. Normal reference curves were derived for both ultrasound measures in each skin site. An online calculator of the percentiles of skin ultrasound measures was developed. RESULTS: Ultrasound–dermal thickness and stiffness measures were higher in men than women in all Rodnan skin sites (except in chest for ultrasound–dermal thickness). Age had also a significant impact in both ultrasound measures, but only in some skin sites. Gender and age percentile curves (97.5th, 95th, 75th, 50th, 25th, 5th, 2.5th) were plotted for each of the measures in each skin site. CONCLUSIONS: Gender and age are strongly associated with skin ultrasound parameters, imposing the need for gender-specific and age-specific reference values. Normal reference percentile curves are provided as a basis for future cooperative work to strengthen its evidence basis, representativeness and refinement regarding potentially influential factors.
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spelling pubmed-96391572022-11-08 Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites Santiago, Tânia Santos, Eduardo José Ferreira Luis, Mariana Gaspar, Catarina Lima, João Caramelo, Francisco da Silva, Jose Antonio Pereira RMD Open Systemic Sclerosis OBJECTIVES: Our primary objective was to establish preliminary normal reference curves for ultrasound–dermal thickness and skin stiffness in the 17 Rodnan skin sites, considering the effect of gender and age on these measures. As an exploratory objective, we investigated the effect of body mass index and the menopause on skin ultrasound measures. METHODS: A cross-sectional study was conducted involving 140 healthy volunteers, aged 20–79 years. Recruitment was stratified by gender and age (10-year categories). Ultrasound–dermal thickness and skin stiffness were assessed by high-frequency ultrasound and shear-wave elastography, respectively, at the 17 Rodnan skin sites. Outcomes were evaluated through a mixed linear model, univariate and multivariate regressions. Normal reference curves were derived for both ultrasound measures in each skin site. An online calculator of the percentiles of skin ultrasound measures was developed. RESULTS: Ultrasound–dermal thickness and stiffness measures were higher in men than women in all Rodnan skin sites (except in chest for ultrasound–dermal thickness). Age had also a significant impact in both ultrasound measures, but only in some skin sites. Gender and age percentile curves (97.5th, 95th, 75th, 50th, 25th, 5th, 2.5th) were plotted for each of the measures in each skin site. CONCLUSIONS: Gender and age are strongly associated with skin ultrasound parameters, imposing the need for gender-specific and age-specific reference values. Normal reference percentile curves are provided as a basis for future cooperative work to strengthen its evidence basis, representativeness and refinement regarding potentially influential factors. BMJ Publishing Group 2022-11-02 /pmc/articles/PMC9639157/ /pubmed/36323485 http://dx.doi.org/10.1136/rmdopen-2022-002577 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Systemic Sclerosis
Santiago, Tânia
Santos, Eduardo José Ferreira
Luis, Mariana
Gaspar, Catarina
Lima, João
Caramelo, Francisco
da Silva, Jose Antonio Pereira
Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites
title Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites
title_full Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites
title_fullStr Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites
title_full_unstemmed Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites
title_short Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites
title_sort normal percentile reference curves for skin ultrasound thickness and stiffness at rodnan sites
topic Systemic Sclerosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639157/
https://www.ncbi.nlm.nih.gov/pubmed/36323485
http://dx.doi.org/10.1136/rmdopen-2022-002577
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