Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses

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Humanity has faced three recent outbreaks of novel betacoronaviruses, emphasizing the need to develop approaches that broadly target coronaviruses. Here, we identify 55 monoclonal antibodies from COVID-19 convalescent donors that bind diverse betacoronavirus spike proteins. Most antibodies targeted...

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Detalles Bibliográficos
Autores principales: Dacon, Cherrelle, Peng, Linghang, Lin, Ting-Hui, Tucker, Courtney, Lee, Chang-Chun D., Cong, Yu, Wang, Lingshu, Purser, Lauren, Cooper, Andrew J.R., Williams, Jazmean K., Pyo, Chul-Woo, Yuan, Meng, Kosik, Ivan, Hu, Zhe, Zhao, Ming, Mohan, Divya, Peterson, Mary, Skinner, Jeff, Dixit, Saurabh, Kollins, Erin, Huzella, Louis, Perry, Donna, Byrum, Russell, Lembirik, Sanae, Murphy, Michael, Zhang, Yi, Yang, Eun Sung, Chen, Man, Leung, Kwanyee, Weinberg, Rona S., Pegu, Amarendra, Geraghty, Daniel E., Davidson, Edgar, Doranz, Benjamin J., Douagi, Iyadh, Moir, Susan, Yewdell, Jonathan W., Schmaljohn, Connie, Crompton, Peter D., Mascola, John R., Holbrook, Michael R., Nemazee, David, Wilson, Ian A., Tan, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639329/
https://www.ncbi.nlm.nih.gov/pubmed/36347257
http://dx.doi.org/10.1016/j.chom.2022.10.010
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