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Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD
INTRODUCTION: Severe chronic obstructive pulmonary disease (COPD) is partly characterized by diminished skeletal muscle oxidative capacity and concurrent dyslipidemia. It is unknown whether such metabolic derangements increase the risk of cardiovascular disease. This study explored associations amon...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639376/ https://www.ncbi.nlm.nih.gov/pubmed/36353139 http://dx.doi.org/10.2147/COPD.S385000 |
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author | Tiller, Nicholas B Kinninger, April Abbasi, Asghar Casaburi, Richard Rossiter, Harry B Budoff, Matthew J Adami, Alessandra |
author_facet | Tiller, Nicholas B Kinninger, April Abbasi, Asghar Casaburi, Richard Rossiter, Harry B Budoff, Matthew J Adami, Alessandra |
author_sort | Tiller, Nicholas B |
collection | PubMed |
description | INTRODUCTION: Severe chronic obstructive pulmonary disease (COPD) is partly characterized by diminished skeletal muscle oxidative capacity and concurrent dyslipidemia. It is unknown whether such metabolic derangements increase the risk of cardiovascular disease. This study explored associations among physical activity (PA), muscle oxidative capacity, and coronary artery calcium (CAC) in COPDGene participants. METHODS: Data from current and former smokers with COPD (n = 75) and normal spirometry (n = 70) were retrospectively analyzed. Physical activity was measured for seven days using triaxial accelerometry (steps/day and vector magnitude units [VMU]) along with the aggregate of self-reported PA amount and PA difficulty using the PROactive D-PPAC instrument. Muscle oxidative capacity (k) was assessed via near-infrared spectroscopy, and CAC was assessed via chest computerized tomography. RESULTS: Relative to controls, COPD patients exhibited higher CAC (median [IQR], 31 [0–431] vs 264 [40–799] HU; p = 0.003), lower k (mean ± SD = 1.66 ± 0.48 vs 1.25 ± 0.37 min(−1); p < 0.001), and lower D-PPAC total score (65.2 ± 9.9 vs 58.8 ± 13.2; p = 0.003). Multivariate analysis—adjusting for age, sex, race, diabetes, disease severity, hyperlipidemia, smoking status, and hypertension—revealed a significant negative association between CAC and D-PPAC total score (β, −0.05; p = 0.013), driven primarily by D-PPAC difficulty score (β, −0.03; p = 0.026). A 1 unit increase in D-PPAC total score was associated with a 5% lower CAC (p = 0.013). There was no association between CAC and either k, steps/day, VMU, or D-PPAC amount. CONCLUSION: Patients with COPD and concomitantly elevated CAC exhibit greater perceptions of difficulty when performing daily activities. This may have implications for exercise adherence and risk of overall physical decline. |
format | Online Article Text |
id | pubmed-9639376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-96393762022-11-08 Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD Tiller, Nicholas B Kinninger, April Abbasi, Asghar Casaburi, Richard Rossiter, Harry B Budoff, Matthew J Adami, Alessandra Int J Chron Obstruct Pulmon Dis Original Research INTRODUCTION: Severe chronic obstructive pulmonary disease (COPD) is partly characterized by diminished skeletal muscle oxidative capacity and concurrent dyslipidemia. It is unknown whether such metabolic derangements increase the risk of cardiovascular disease. This study explored associations among physical activity (PA), muscle oxidative capacity, and coronary artery calcium (CAC) in COPDGene participants. METHODS: Data from current and former smokers with COPD (n = 75) and normal spirometry (n = 70) were retrospectively analyzed. Physical activity was measured for seven days using triaxial accelerometry (steps/day and vector magnitude units [VMU]) along with the aggregate of self-reported PA amount and PA difficulty using the PROactive D-PPAC instrument. Muscle oxidative capacity (k) was assessed via near-infrared spectroscopy, and CAC was assessed via chest computerized tomography. RESULTS: Relative to controls, COPD patients exhibited higher CAC (median [IQR], 31 [0–431] vs 264 [40–799] HU; p = 0.003), lower k (mean ± SD = 1.66 ± 0.48 vs 1.25 ± 0.37 min(−1); p < 0.001), and lower D-PPAC total score (65.2 ± 9.9 vs 58.8 ± 13.2; p = 0.003). Multivariate analysis—adjusting for age, sex, race, diabetes, disease severity, hyperlipidemia, smoking status, and hypertension—revealed a significant negative association between CAC and D-PPAC total score (β, −0.05; p = 0.013), driven primarily by D-PPAC difficulty score (β, −0.03; p = 0.026). A 1 unit increase in D-PPAC total score was associated with a 5% lower CAC (p = 0.013). There was no association between CAC and either k, steps/day, VMU, or D-PPAC amount. CONCLUSION: Patients with COPD and concomitantly elevated CAC exhibit greater perceptions of difficulty when performing daily activities. This may have implications for exercise adherence and risk of overall physical decline. Dove 2022-11-03 /pmc/articles/PMC9639376/ /pubmed/36353139 http://dx.doi.org/10.2147/COPD.S385000 Text en © 2022 Tiller et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Tiller, Nicholas B Kinninger, April Abbasi, Asghar Casaburi, Richard Rossiter, Harry B Budoff, Matthew J Adami, Alessandra Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD |
title | Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD |
title_full | Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD |
title_fullStr | Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD |
title_full_unstemmed | Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD |
title_short | Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD |
title_sort | physical activity, muscle oxidative capacity, and coronary artery calcium in smokers with and without copd |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639376/ https://www.ncbi.nlm.nih.gov/pubmed/36353139 http://dx.doi.org/10.2147/COPD.S385000 |
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