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Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation. Sugars (glucose, fructose, galactose) and aldehydes (glyoxa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639497/ https://www.ncbi.nlm.nih.gov/pubmed/36325591 http://dx.doi.org/10.1080/14756366.2022.2137161 |
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author | Nesterowicz, Miłosz Żendzian-Piotrowska, Małgorzata Ładny, Jerzy Robert Zalewska, Anna Maciejczyk, Mateusz |
author_facet | Nesterowicz, Miłosz Żendzian-Piotrowska, Małgorzata Ładny, Jerzy Robert Zalewska, Anna Maciejczyk, Mateusz |
author_sort | Nesterowicz, Miłosz |
collection | PubMed |
description | An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation. Sugars (glucose, fructose, galactose) and aldehydes (glyoxal, methylglyoxal) were used as glycation agents, and chloramine T was used as an oxidant. Glycoxidation biomarkers in albumin treated with amantadine were generally not different from the control group (glycation/oxidation factors), indicating that the drug did not affect oxidation and glycation processes. Molecular docking analysis did not reveal strong binding sites of amantadine on the bovine serum albumin structure. Although amantadine poorly scavenged hydroxyl radical and hydrogen peroxide, it had significantly lower antioxidant and antiglycation effect than all protein oxidation and glycation inhibitors. In some cases, amantadine even demonstrated glycoxidant, proglycation, and prooxidant properties. In summary, amantadine exhibited weak antioxidant properties and a lack of antiglycation activity. |
format | Online Article Text |
id | pubmed-9639497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-96394972022-11-08 Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study Nesterowicz, Miłosz Żendzian-Piotrowska, Małgorzata Ładny, Jerzy Robert Zalewska, Anna Maciejczyk, Mateusz J Enzyme Inhib Med Chem Research Paper An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation. Sugars (glucose, fructose, galactose) and aldehydes (glyoxal, methylglyoxal) were used as glycation agents, and chloramine T was used as an oxidant. Glycoxidation biomarkers in albumin treated with amantadine were generally not different from the control group (glycation/oxidation factors), indicating that the drug did not affect oxidation and glycation processes. Molecular docking analysis did not reveal strong binding sites of amantadine on the bovine serum albumin structure. Although amantadine poorly scavenged hydroxyl radical and hydrogen peroxide, it had significantly lower antioxidant and antiglycation effect than all protein oxidation and glycation inhibitors. In some cases, amantadine even demonstrated glycoxidant, proglycation, and prooxidant properties. In summary, amantadine exhibited weak antioxidant properties and a lack of antiglycation activity. Taylor & Francis 2022-11-02 /pmc/articles/PMC9639497/ /pubmed/36325591 http://dx.doi.org/10.1080/14756366.2022.2137161 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Nesterowicz, Miłosz Żendzian-Piotrowska, Małgorzata Ładny, Jerzy Robert Zalewska, Anna Maciejczyk, Mateusz Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
title | Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
title_full | Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
title_fullStr | Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
title_full_unstemmed | Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
title_short | Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
title_sort | antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639497/ https://www.ncbi.nlm.nih.gov/pubmed/36325591 http://dx.doi.org/10.1080/14756366.2022.2137161 |
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