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Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study

An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation. Sugars (glucose, fructose, galactose) and aldehydes (glyoxa...

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Autores principales: Nesterowicz, Miłosz, Żendzian-Piotrowska, Małgorzata, Ładny, Jerzy Robert, Zalewska, Anna, Maciejczyk, Mateusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639497/
https://www.ncbi.nlm.nih.gov/pubmed/36325591
http://dx.doi.org/10.1080/14756366.2022.2137161
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author Nesterowicz, Miłosz
Żendzian-Piotrowska, Małgorzata
Ładny, Jerzy Robert
Zalewska, Anna
Maciejczyk, Mateusz
author_facet Nesterowicz, Miłosz
Żendzian-Piotrowska, Małgorzata
Ładny, Jerzy Robert
Zalewska, Anna
Maciejczyk, Mateusz
author_sort Nesterowicz, Miłosz
collection PubMed
description An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation. Sugars (glucose, fructose, galactose) and aldehydes (glyoxal, methylglyoxal) were used as glycation agents, and chloramine T was used as an oxidant. Glycoxidation biomarkers in albumin treated with amantadine were generally not different from the control group (glycation/oxidation factors), indicating that the drug did not affect oxidation and glycation processes. Molecular docking analysis did not reveal strong binding sites of amantadine on the bovine serum albumin structure. Although amantadine poorly scavenged hydroxyl radical and hydrogen peroxide, it had significantly lower antioxidant and antiglycation effect than all protein oxidation and glycation inhibitors. In some cases, amantadine even demonstrated glycoxidant, proglycation, and prooxidant properties. In summary, amantadine exhibited weak antioxidant properties and a lack of antiglycation activity.
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spelling pubmed-96394972022-11-08 Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study Nesterowicz, Miłosz Żendzian-Piotrowska, Małgorzata Ładny, Jerzy Robert Zalewska, Anna Maciejczyk, Mateusz J Enzyme Inhib Med Chem Research Paper An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation. Sugars (glucose, fructose, galactose) and aldehydes (glyoxal, methylglyoxal) were used as glycation agents, and chloramine T was used as an oxidant. Glycoxidation biomarkers in albumin treated with amantadine were generally not different from the control group (glycation/oxidation factors), indicating that the drug did not affect oxidation and glycation processes. Molecular docking analysis did not reveal strong binding sites of amantadine on the bovine serum albumin structure. Although amantadine poorly scavenged hydroxyl radical and hydrogen peroxide, it had significantly lower antioxidant and antiglycation effect than all protein oxidation and glycation inhibitors. In some cases, amantadine even demonstrated glycoxidant, proglycation, and prooxidant properties. In summary, amantadine exhibited weak antioxidant properties and a lack of antiglycation activity. Taylor & Francis 2022-11-02 /pmc/articles/PMC9639497/ /pubmed/36325591 http://dx.doi.org/10.1080/14756366.2022.2137161 Text en © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Nesterowicz, Miłosz
Żendzian-Piotrowska, Małgorzata
Ładny, Jerzy Robert
Zalewska, Anna
Maciejczyk, Mateusz
Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
title Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
title_full Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
title_fullStr Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
title_full_unstemmed Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
title_short Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
title_sort antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639497/
https://www.ncbi.nlm.nih.gov/pubmed/36325591
http://dx.doi.org/10.1080/14756366.2022.2137161
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