Utilizing Nonequilibrium Isotope Enrichments to Dramatically Increase Turnover Measurement Ranges in Single Biopsy Samples from Humans

[Image: see text] The synthesis of new proteins and the degradation of old proteins in vivo can be quantified in serial samples using metabolic isotope labeling to measure turnover. Because serial biopsies in humans are impractical, we set out to develop a method to calculate the turnover rates of p...

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Detalles Bibliográficos
Autores principales: Naylor, Bradley C., Anderson, Christian N. K., Hadfield, Marcus, Parkinson, David H., Ahlstrom, Austin, Hannemann, Austin, Quilling, Chad R., Cutler, Kyle J., Denton, Russell L., Adamson, Robert, Angel, Thomas E., Burlett, Rebecca S., Hafen, Paul S., Dallon, John. C., Transtrum, Mark K., Hyldahl, Robert D., Price, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639613/
https://www.ncbi.nlm.nih.gov/pubmed/36099490
http://dx.doi.org/10.1021/acs.jproteome.2c00380

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