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Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface
Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639622/ https://www.ncbi.nlm.nih.gov/pubmed/36196979 http://dx.doi.org/10.1002/acn3.51676 |
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| author | Vermunt, Lisa Otte, Marco Verberk, Inge M. W. Killestein, Joep Lemstra, Afina W. van der Flier, Wiesje M. Pijnenburg, Yolande A. L. Vijverberg, Everard G. B. Bouwman, Femke H. Gravesteijn, Gido van de Berg, Wilma D. J. Scheltens, Philip van Harten, Argonde C. Willemse, Eline A. J. Teunissen, Charlotte E. |
| author_facet | Vermunt, Lisa Otte, Marco Verberk, Inge M. W. Killestein, Joep Lemstra, Afina W. van der Flier, Wiesje M. Pijnenburg, Yolande A. L. Vijverberg, Everard G. B. Bouwman, Femke H. Gravesteijn, Gido van de Berg, Wilma D. J. Scheltens, Philip van Harten, Argonde C. Willemse, Eline A. J. Teunissen, Charlotte E. |
| author_sort | Vermunt, Lisa |
| collection | PubMed |
| description | Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19–85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https://mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age‐dependent biomarkers in neurology. |
| format | Online Article Text |
| id | pubmed-9639622 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96396222022-11-14 Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface Vermunt, Lisa Otte, Marco Verberk, Inge M. W. Killestein, Joep Lemstra, Afina W. van der Flier, Wiesje M. Pijnenburg, Yolande A. L. Vijverberg, Everard G. B. Bouwman, Femke H. Gravesteijn, Gido van de Berg, Wilma D. J. Scheltens, Philip van Harten, Argonde C. Willemse, Eline A. J. Teunissen, Charlotte E. Ann Clin Transl Neurol Brief Communications Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19–85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https://mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age‐dependent biomarkers in neurology. John Wiley and Sons Inc. 2022-10-05 /pmc/articles/PMC9639622/ /pubmed/36196979 http://dx.doi.org/10.1002/acn3.51676 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Brief Communications Vermunt, Lisa Otte, Marco Verberk, Inge M. W. Killestein, Joep Lemstra, Afina W. van der Flier, Wiesje M. Pijnenburg, Yolande A. L. Vijverberg, Everard G. B. Bouwman, Femke H. Gravesteijn, Gido van de Berg, Wilma D. J. Scheltens, Philip van Harten, Argonde C. Willemse, Eline A. J. Teunissen, Charlotte E. Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| title | Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| title_full | Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| title_fullStr | Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| title_full_unstemmed | Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| title_short | Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| title_sort | age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639622/ https://www.ncbi.nlm.nih.gov/pubmed/36196979 http://dx.doi.org/10.1002/acn3.51676 |
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