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8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity

8-Aminoguanine and 8-aminoguanosine (via metabolism to 8-aminoguanine) are endogenous 8-aminopurines that induce diuresis, natriuresis, and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase); moreover, both 8-aminopurines cause antikaliuresis by other mechanisms. Because 8-aminoinosin...

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Detalles Bibliográficos
Autores principales:	Jackson, Edwin K., Menshikova, Elizabeth V., Ritov, Vladimir B., Mi, Zaichuan, Birder, Lori A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:	Gastrointestinal, Hepatic, Pulmonary, and Renal
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639651/ https://www.ncbi.nlm.nih.gov/pubmed/35609923 http://dx.doi.org/10.1124/jpet.122.001221

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