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Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography

PURPOSE: To examine the impact of reticular pseudodrusen (RPD) on choriocapillaris blood flow and choroidal structure in individuals with intermediate age-related macular degeneration (AMD). METHODS: Individuals with bilateral large drusen underwent optical coherence tomography (OCT), color fundus p...

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Autores principales: Wu, Zhichao, Zhou, Xiao, Chu, Zhongdi, Gregori, Giovanni, Wang, Ruikang K., Rosenfeld, Philip J., Guymer, Robyn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639673/
https://www.ncbi.nlm.nih.gov/pubmed/36318196
http://dx.doi.org/10.1167/iovs.63.12.1
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author Wu, Zhichao
Zhou, Xiao
Chu, Zhongdi
Gregori, Giovanni
Wang, Ruikang K.
Rosenfeld, Philip J.
Guymer, Robyn H.
author_facet Wu, Zhichao
Zhou, Xiao
Chu, Zhongdi
Gregori, Giovanni
Wang, Ruikang K.
Rosenfeld, Philip J.
Guymer, Robyn H.
author_sort Wu, Zhichao
collection PubMed
description PURPOSE: To examine the impact of reticular pseudodrusen (RPD) on choriocapillaris blood flow and choroidal structure in individuals with intermediate age-related macular degeneration (AMD). METHODS: Individuals with bilateral large drusen underwent optical coherence tomography (OCT), color fundus photography, near-infrared reflectance, and fundus autofluorescence imaging to determine the presence of RPD. These participants also underwent swept-source OCT angiography (SS-OCTA) imaging to determine (1) choriocapillaris flow deficit (FD) parameters, including the percentage, mean size, and number of FDs present; and (2) choroidal structural parameters, including mean choroidal thickness and choroidal vascularity index. Differences in these parameters between eyes with and without coexistent RPD were examined with and without adjustment for potential key confounders such as drusen volume from the SS-OCTA scans and age. RESULTS: This study included 102 eyes from 51 individuals with bilateral large drusen, and the analyses showed that there were no significant differences in the choriocapillaris FD parameters (P ≥ 0.062 for all) and choroidal structural parameters (P ≥ 0.059 for all), with or without adjustment for potential confounders in this cohort. However, the percentage of FDs and the mean FD size were both significantly greater with increasing drusen volume (P ≤ 0.038 for both). CONCLUSIONS: The coexistence of RPD in eyes of individuals with intermediate AMD was not associated with significant impairments in choriocapillaris blood flow and choroidal vascular structural changes, with or without adjustment for key confounders. These findings suggest that macular changes in these vascular parameters may not be associated with the presence of RPD.
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spelling pubmed-96396732022-11-08 Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography Wu, Zhichao Zhou, Xiao Chu, Zhongdi Gregori, Giovanni Wang, Ruikang K. Rosenfeld, Philip J. Guymer, Robyn H. Invest Ophthalmol Vis Sci Retina PURPOSE: To examine the impact of reticular pseudodrusen (RPD) on choriocapillaris blood flow and choroidal structure in individuals with intermediate age-related macular degeneration (AMD). METHODS: Individuals with bilateral large drusen underwent optical coherence tomography (OCT), color fundus photography, near-infrared reflectance, and fundus autofluorescence imaging to determine the presence of RPD. These participants also underwent swept-source OCT angiography (SS-OCTA) imaging to determine (1) choriocapillaris flow deficit (FD) parameters, including the percentage, mean size, and number of FDs present; and (2) choroidal structural parameters, including mean choroidal thickness and choroidal vascularity index. Differences in these parameters between eyes with and without coexistent RPD were examined with and without adjustment for potential key confounders such as drusen volume from the SS-OCTA scans and age. RESULTS: This study included 102 eyes from 51 individuals with bilateral large drusen, and the analyses showed that there were no significant differences in the choriocapillaris FD parameters (P ≥ 0.062 for all) and choroidal structural parameters (P ≥ 0.059 for all), with or without adjustment for potential confounders in this cohort. However, the percentage of FDs and the mean FD size were both significantly greater with increasing drusen volume (P ≤ 0.038 for both). CONCLUSIONS: The coexistence of RPD in eyes of individuals with intermediate AMD was not associated with significant impairments in choriocapillaris blood flow and choroidal vascular structural changes, with or without adjustment for key confounders. These findings suggest that macular changes in these vascular parameters may not be associated with the presence of RPD. The Association for Research in Vision and Ophthalmology 2022-11-01 /pmc/articles/PMC9639673/ /pubmed/36318196 http://dx.doi.org/10.1167/iovs.63.12.1 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Retina
Wu, Zhichao
Zhou, Xiao
Chu, Zhongdi
Gregori, Giovanni
Wang, Ruikang K.
Rosenfeld, Philip J.
Guymer, Robyn H.
Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
title Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
title_full Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
title_fullStr Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
title_full_unstemmed Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
title_short Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
title_sort impact of reticular pseudodrusen on choriocapillaris flow deficits and choroidal structure on optical coherence tomography angiography
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639673/
https://www.ncbi.nlm.nih.gov/pubmed/36318196
http://dx.doi.org/10.1167/iovs.63.12.1
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