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Vaginal microbiota and HPV clearance: A longitudinal study

Although vaginal microbiota (VM) may interact with human papillomavirus (HPV) infection and clearance, longitudinal data remain very limited. We aimed to investigate the association between VM at baseline and the clearance of high-risk HPV (HR-HPV) infection within 12 months. Cervical swabs were col...

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Autores principales: Shi, Wenpei, Zhu, Haiyan, Yuan, Lei, Chen, Xiaoyue, Huang, Xiaojie, Wang, Kai, Li, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639776/
https://www.ncbi.nlm.nih.gov/pubmed/36353544
http://dx.doi.org/10.3389/fonc.2022.955150
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author Shi, Wenpei
Zhu, Haiyan
Yuan, Lei
Chen, Xiaoyue
Huang, Xiaojie
Wang, Kai
Li, Zhen
author_facet Shi, Wenpei
Zhu, Haiyan
Yuan, Lei
Chen, Xiaoyue
Huang, Xiaojie
Wang, Kai
Li, Zhen
author_sort Shi, Wenpei
collection PubMed
description Although vaginal microbiota (VM) may interact with human papillomavirus (HPV) infection and clearance, longitudinal data remain very limited. We aimed to investigate the association between VM at baseline and the clearance of high-risk HPV (HR-HPV) infection within 12 months. Cervical swabs were collected at diagnosis from 85 patients with HR-HPV infection and histologically confirmed cervical lesions, including cervicitis, low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion. Microbiome analysis was performed using 16S rRNA gene sequencing. Among the 73 women included in the analyses, HPV clearance was observed in 58.9% of the patients within 12 months. No significant difference was observed between the HPV-cleared and HPV-uncleared groups regarding age, disease stage, HPV subtype, VM community state types, and VM diversity (α and β). Women with the depletion of enterococcus ASV_62 and enrichment in Lactobacillus iners at baseline were less likely to have HPV clearance at month 12. Further analysis revealed a significant negative association between high abundance of L. iners and HPV clearance in patients who received non-operative treatment (OR = 3.94, p = 0.041), but not in those who received operative treatment (OR = 1.86, p = 0.660). Our findings provide new evidence for the potential role of VM in the persistent HR-HPV infections.
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spelling pubmed-96397762022-11-08 Vaginal microbiota and HPV clearance: A longitudinal study Shi, Wenpei Zhu, Haiyan Yuan, Lei Chen, Xiaoyue Huang, Xiaojie Wang, Kai Li, Zhen Front Oncol Oncology Although vaginal microbiota (VM) may interact with human papillomavirus (HPV) infection and clearance, longitudinal data remain very limited. We aimed to investigate the association between VM at baseline and the clearance of high-risk HPV (HR-HPV) infection within 12 months. Cervical swabs were collected at diagnosis from 85 patients with HR-HPV infection and histologically confirmed cervical lesions, including cervicitis, low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion. Microbiome analysis was performed using 16S rRNA gene sequencing. Among the 73 women included in the analyses, HPV clearance was observed in 58.9% of the patients within 12 months. No significant difference was observed between the HPV-cleared and HPV-uncleared groups regarding age, disease stage, HPV subtype, VM community state types, and VM diversity (α and β). Women with the depletion of enterococcus ASV_62 and enrichment in Lactobacillus iners at baseline were less likely to have HPV clearance at month 12. Further analysis revealed a significant negative association between high abundance of L. iners and HPV clearance in patients who received non-operative treatment (OR = 3.94, p = 0.041), but not in those who received operative treatment (OR = 1.86, p = 0.660). Our findings provide new evidence for the potential role of VM in the persistent HR-HPV infections. Frontiers Media S.A. 2022-10-24 /pmc/articles/PMC9639776/ /pubmed/36353544 http://dx.doi.org/10.3389/fonc.2022.955150 Text en Copyright © 2022 Shi, Zhu, Yuan, Chen, Huang, Wang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Shi, Wenpei
Zhu, Haiyan
Yuan, Lei
Chen, Xiaoyue
Huang, Xiaojie
Wang, Kai
Li, Zhen
Vaginal microbiota and HPV clearance: A longitudinal study
title Vaginal microbiota and HPV clearance: A longitudinal study
title_full Vaginal microbiota and HPV clearance: A longitudinal study
title_fullStr Vaginal microbiota and HPV clearance: A longitudinal study
title_full_unstemmed Vaginal microbiota and HPV clearance: A longitudinal study
title_short Vaginal microbiota and HPV clearance: A longitudinal study
title_sort vaginal microbiota and hpv clearance: a longitudinal study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639776/
https://www.ncbi.nlm.nih.gov/pubmed/36353544
http://dx.doi.org/10.3389/fonc.2022.955150
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