A Rare Case Report of Sitagliptin-Induced Angioedema

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is used for the treatment of type 2 diabetes mellitus. Sitagliptin-induced angioedema has increased with the simultaneous use of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors. We present a rare case of a 50-year-old female...

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Autores principales: Sharma, Nava R, Sharma, Bharosa, Lamichhane, Saral, Pokhrel, Madalasa, Shrestha, Prajwal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640175/
https://www.ncbi.nlm.nih.gov/pubmed/36381841
http://dx.doi.org/10.7759/cureus.30077
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author Sharma, Nava R
Sharma, Bharosa
Lamichhane, Saral
Pokhrel, Madalasa
Shrestha, Prajwal
author_facet Sharma, Nava R
Sharma, Bharosa
Lamichhane, Saral
Pokhrel, Madalasa
Shrestha, Prajwal
author_sort Sharma, Nava R
collection PubMed
description Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is used for the treatment of type 2 diabetes mellitus. Sitagliptin-induced angioedema has increased with the simultaneous use of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors. We present a rare case of a 50-year-old female diagnosed with sitagliptin-induced angioedema. On examination, she had both upper and lower lip swelling without any respiratory compromise. On further investigation, her C1 esterase inhibitor level was normal. After stopping sitagliptin, her symptoms resolved. Thus, cautious use of dipeptidyl peptidase-4 inhibitor is advised.
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spelling pubmed-96401752022-11-14 A Rare Case Report of Sitagliptin-Induced Angioedema Sharma, Nava R Sharma, Bharosa Lamichhane, Saral Pokhrel, Madalasa Shrestha, Prajwal Cureus Endocrinology/Diabetes/Metabolism Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is used for the treatment of type 2 diabetes mellitus. Sitagliptin-induced angioedema has increased with the simultaneous use of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors. We present a rare case of a 50-year-old female diagnosed with sitagliptin-induced angioedema. On examination, she had both upper and lower lip swelling without any respiratory compromise. On further investigation, her C1 esterase inhibitor level was normal. After stopping sitagliptin, her symptoms resolved. Thus, cautious use of dipeptidyl peptidase-4 inhibitor is advised. Cureus 2022-10-08 /pmc/articles/PMC9640175/ /pubmed/36381841 http://dx.doi.org/10.7759/cureus.30077 Text en Copyright © 2022, Sharma et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Sharma, Nava R
Sharma, Bharosa
Lamichhane, Saral
Pokhrel, Madalasa
Shrestha, Prajwal
A Rare Case Report of Sitagliptin-Induced Angioedema
title A Rare Case Report of Sitagliptin-Induced Angioedema
title_full A Rare Case Report of Sitagliptin-Induced Angioedema
title_fullStr A Rare Case Report of Sitagliptin-Induced Angioedema
title_full_unstemmed A Rare Case Report of Sitagliptin-Induced Angioedema
title_short A Rare Case Report of Sitagliptin-Induced Angioedema
title_sort rare case report of sitagliptin-induced angioedema
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640175/
https://www.ncbi.nlm.nih.gov/pubmed/36381841
http://dx.doi.org/10.7759/cureus.30077
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