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Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study
BACKGROUND: Mitral annular disjunction is the atrial displacement of the mural mitral valve leaflet hinge point within the atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in the general population is not known. OBJECTIVES: The...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640354/ https://www.ncbi.nlm.nih.gov/pubmed/36280553 http://dx.doi.org/10.1016/j.jcmg.2022.07.015 |
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author | Zugwitz, Dasa Fung, Kenneth Aung, Nay Rauseo, Elisa McCracken, Celeste Cooper, Jackie El Messaoudi, Saloua Anderson, Robert H. Piechnik, Stefan K. Neubauer, Stefan Petersen, Steffen E. Nijveldt, Robin |
author_facet | Zugwitz, Dasa Fung, Kenneth Aung, Nay Rauseo, Elisa McCracken, Celeste Cooper, Jackie El Messaoudi, Saloua Anderson, Robert H. Piechnik, Stefan K. Neubauer, Stefan Petersen, Steffen E. Nijveldt, Robin |
author_sort | Zugwitz, Dasa |
collection | PubMed |
description | BACKGROUND: Mitral annular disjunction is the atrial displacement of the mural mitral valve leaflet hinge point within the atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in the general population is not known. OBJECTIVES: The purpose of this study was to assess the frequency of occurrence and extent of mitral annular disjunction in a large population cohort. METHODS: The authors assessed the cardiac magnetic resonance (CMR) images in 2,646 Caucasian subjects enrolled in the UK Biobank imaging study, measuring the length of disjunction at 4 points around the mitral annulus, assessing for presence of prolapse or billowing of the leaflets, and for curling motion of the inferolateral left ventricular wall. RESULTS: From 2,607 included participants, the authors found disjunction in 1,990 (76%) cases, most commonly at the anterior and inferior ventricular wall. The authors found inferolateral disjunction, reported as clinically important, in 134 (5%) cases. Prolapse was more frequent in subjects with disjunction (odds ratio [OR]: 2.5; P = 0.02), with positive associations found between systolic curling and disjunction at any site (OR: 3.6; P < 0.01), and systolic curling and prolapse (OR: 71.9; P < 0.01). CONCLUSIONS: This large-scale study shows that disjunction is a common finding when using CMR. Disjunction at the inferolateral ventricular wall, however, was rare. The authors found associations between disjunction and both prolapse and billowing of the mural mitral valve leaflet. These findings support the notion that only extensive inferolateral disjunction, when found, warrants consideration of further investigation, but disjunction elsewhere in the annulus should be considered a normal finding. |
format | Online Article Text |
id | pubmed-9640354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96403542022-11-14 Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study Zugwitz, Dasa Fung, Kenneth Aung, Nay Rauseo, Elisa McCracken, Celeste Cooper, Jackie El Messaoudi, Saloua Anderson, Robert H. Piechnik, Stefan K. Neubauer, Stefan Petersen, Steffen E. Nijveldt, Robin JACC Cardiovasc Imaging Mini-Focus: Mitral Valve Regurgitation: Emerging Etiologies BACKGROUND: Mitral annular disjunction is the atrial displacement of the mural mitral valve leaflet hinge point within the atrioventricular junction. Said to be associated with malignant ventricular arrhythmias and sudden death, its prevalence in the general population is not known. OBJECTIVES: The purpose of this study was to assess the frequency of occurrence and extent of mitral annular disjunction in a large population cohort. METHODS: The authors assessed the cardiac magnetic resonance (CMR) images in 2,646 Caucasian subjects enrolled in the UK Biobank imaging study, measuring the length of disjunction at 4 points around the mitral annulus, assessing for presence of prolapse or billowing of the leaflets, and for curling motion of the inferolateral left ventricular wall. RESULTS: From 2,607 included participants, the authors found disjunction in 1,990 (76%) cases, most commonly at the anterior and inferior ventricular wall. The authors found inferolateral disjunction, reported as clinically important, in 134 (5%) cases. Prolapse was more frequent in subjects with disjunction (odds ratio [OR]: 2.5; P = 0.02), with positive associations found between systolic curling and disjunction at any site (OR: 3.6; P < 0.01), and systolic curling and prolapse (OR: 71.9; P < 0.01). CONCLUSIONS: This large-scale study shows that disjunction is a common finding when using CMR. Disjunction at the inferolateral ventricular wall, however, was rare. The authors found associations between disjunction and both prolapse and billowing of the mural mitral valve leaflet. These findings support the notion that only extensive inferolateral disjunction, when found, warrants consideration of further investigation, but disjunction elsewhere in the annulus should be considered a normal finding. Elsevier 2022-11 /pmc/articles/PMC9640354/ /pubmed/36280553 http://dx.doi.org/10.1016/j.jcmg.2022.07.015 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Mini-Focus: Mitral Valve Regurgitation: Emerging Etiologies Zugwitz, Dasa Fung, Kenneth Aung, Nay Rauseo, Elisa McCracken, Celeste Cooper, Jackie El Messaoudi, Saloua Anderson, Robert H. Piechnik, Stefan K. Neubauer, Stefan Petersen, Steffen E. Nijveldt, Robin Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study |
title | Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study |
title_full | Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study |
title_fullStr | Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study |
title_full_unstemmed | Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study |
title_short | Mitral Annular Disjunction Assessed Using CMR Imaging: Insights From the UK Biobank Population Study |
title_sort | mitral annular disjunction assessed using cmr imaging: insights from the uk biobank population study |
topic | Mini-Focus: Mitral Valve Regurgitation: Emerging Etiologies |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640354/ https://www.ncbi.nlm.nih.gov/pubmed/36280553 http://dx.doi.org/10.1016/j.jcmg.2022.07.015 |
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