Cargando…

Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report

Disorders of consciousness (DOC) are one of the most frequent complications in patients after severe brain injury, mainly caused by trauma, stroke, and anoxia. With the development of neuromodulation techniques, novel therapies including deep brain stimulation (DBS) and spinal cord stimulation (SCS)...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Yi, He, Qiheng, He, Jianghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640422/
https://www.ncbi.nlm.nih.gov/pubmed/36388222
http://dx.doi.org/10.3389/fneur.2022.968932
_version_ 1784825847465639936
author Yang, Yi
He, Qiheng
He, Jianghong
author_facet Yang, Yi
He, Qiheng
He, Jianghong
author_sort Yang, Yi
collection PubMed
description Disorders of consciousness (DOC) are one of the most frequent complications in patients after severe brain injury, mainly caused by trauma, stroke, and anoxia. With the development of neuromodulation techniques, novel therapies including deep brain stimulation (DBS) and spinal cord stimulation (SCS) have been employed to treat DOC. Here, we report the case of a DOC patient receiving short-term SCS (st-SCS) treatment and showing improvement monitored by resting-state fMRI (rs-fMRI) and quantitative EEG (qEEG). A 35-year-old male with severe traumatic brain injury remained comatose for 3 months. The patient was evaluated using JFK coma recovery scale—revised (CRS-R) and showed no improvement within 1 month. He received st-SCS surgery 93 days after the injury and the stimulation was applied the day after surgery. He regained communication according to instructions on day 21 after surgery and improved from a vegetative state/unwakefulness syndrome to an emergence from a minimally conscious state. To our knowledge, this report is the first published case of st-SCS in a patient with DOC. These results shed light that st-SCS may be effective in treating certain patients with DOC, which may reduce patients' suffering during treatment and lessen financial burden.
format Online
Article
Text
id pubmed-9640422
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96404222022-11-15 Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report Yang, Yi He, Qiheng He, Jianghong Front Neurol Neurology Disorders of consciousness (DOC) are one of the most frequent complications in patients after severe brain injury, mainly caused by trauma, stroke, and anoxia. With the development of neuromodulation techniques, novel therapies including deep brain stimulation (DBS) and spinal cord stimulation (SCS) have been employed to treat DOC. Here, we report the case of a DOC patient receiving short-term SCS (st-SCS) treatment and showing improvement monitored by resting-state fMRI (rs-fMRI) and quantitative EEG (qEEG). A 35-year-old male with severe traumatic brain injury remained comatose for 3 months. The patient was evaluated using JFK coma recovery scale—revised (CRS-R) and showed no improvement within 1 month. He received st-SCS surgery 93 days after the injury and the stimulation was applied the day after surgery. He regained communication according to instructions on day 21 after surgery and improved from a vegetative state/unwakefulness syndrome to an emergence from a minimally conscious state. To our knowledge, this report is the first published case of st-SCS in a patient with DOC. These results shed light that st-SCS may be effective in treating certain patients with DOC, which may reduce patients' suffering during treatment and lessen financial burden. Frontiers Media S.A. 2022-10-25 /pmc/articles/PMC9640422/ /pubmed/36388222 http://dx.doi.org/10.3389/fneur.2022.968932 Text en Copyright © 2022 Yang, He and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Yang, Yi
He, Qiheng
He, Jianghong
Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
title Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
title_full Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
title_fullStr Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
title_full_unstemmed Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
title_short Short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fMRI and qEEG: The first case report
title_sort short-term spinal cord stimulation in treating disorders of consciousness monitored by resting-state fmri and qeeg: the first case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640422/
https://www.ncbi.nlm.nih.gov/pubmed/36388222
http://dx.doi.org/10.3389/fneur.2022.968932
work_keys_str_mv AT yangyi shorttermspinalcordstimulationintreatingdisordersofconsciousnessmonitoredbyrestingstatefmriandqeegthefirstcasereport
AT heqiheng shorttermspinalcordstimulationintreatingdisordersofconsciousnessmonitoredbyrestingstatefmriandqeegthefirstcasereport
AT hejianghong shorttermspinalcordstimulationintreatingdisordersofconsciousnessmonitoredbyrestingstatefmriandqeegthefirstcasereport