Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy

Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are lipid pools in cells that change dynamically in response to t...

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Autores principales: Yang, Ming, Luo, Shilu, Yang, Jinfei, Chen, Wei, He, Liyu, Liu, Di, Zhao, Li, Wang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640443/
https://www.ncbi.nlm.nih.gov/pubmed/36387849
http://dx.doi.org/10.3389/fendo.2022.1017387
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author Yang, Ming
Luo, Shilu
Yang, Jinfei
Chen, Wei
He, Liyu
Liu, Di
Zhao, Li
Wang, Xi
author_facet Yang, Ming
Luo, Shilu
Yang, Jinfei
Chen, Wei
He, Liyu
Liu, Di
Zhao, Li
Wang, Xi
author_sort Yang, Ming
collection PubMed
description Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are lipid pools in cells that change dynamically in response to the cellular energy needs. The LDs and mitochondria are connected through a part of the mitochondria known as the peridroplet mitochondria (PDM). In this review, we summarize the definition, detection methods, and function of the PDM. Finally, we discuss the research status of PDM in DN and the possibility of its use as a therapeutic target.
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spelling pubmed-96404432022-11-15 Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy Yang, Ming Luo, Shilu Yang, Jinfei Chen, Wei He, Liyu Liu, Di Zhao, Li Wang, Xi Front Endocrinol (Lausanne) Endocrinology Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are lipid pools in cells that change dynamically in response to the cellular energy needs. The LDs and mitochondria are connected through a part of the mitochondria known as the peridroplet mitochondria (PDM). In this review, we summarize the definition, detection methods, and function of the PDM. Finally, we discuss the research status of PDM in DN and the possibility of its use as a therapeutic target. Frontiers Media S.A. 2022-10-25 /pmc/articles/PMC9640443/ /pubmed/36387849 http://dx.doi.org/10.3389/fendo.2022.1017387 Text en Copyright © 2022 Yang, Luo, Yang, Chen, He, Liu, Zhao and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Ming
Luo, Shilu
Yang, Jinfei
Chen, Wei
He, Liyu
Liu, Di
Zhao, Li
Wang, Xi
Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
title Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
title_full Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
title_fullStr Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
title_full_unstemmed Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
title_short Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
title_sort lipid droplet - mitochondria coupling: a novel lipid metabolism regulatory hub in diabetic nephropathy
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640443/
https://www.ncbi.nlm.nih.gov/pubmed/36387849
http://dx.doi.org/10.3389/fendo.2022.1017387
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