Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron

ABSTRACT: Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C(6) unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were det...

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Autores principales: Hu, Ya-Li, Li, Xing-Ren, Xu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640506/
https://www.ncbi.nlm.nih.gov/pubmed/36342546
http://dx.doi.org/10.1007/s13659-022-00362-z
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author Hu, Ya-Li
Li, Xing-Ren
Xu, Gang
author_facet Hu, Ya-Li
Li, Xing-Ren
Xu, Gang
author_sort Hu, Ya-Li
collection PubMed
description ABSTRACT: Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C(6) unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray diffraction data. Biologically, compound 1 inhibited cell proliferation in LoVo, SW480, and HCT116 cell lines (IC(50) = 12.30–24.57 µM). GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00362-z.
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spelling pubmed-96405062022-11-15 Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron Hu, Ya-Li Li, Xing-Ren Xu, Gang Nat Prod Bioprospect Short Communication ABSTRACT: Carascynol A, an unprecedented 4/9/8 ring system hybrid with a peroxide bridge, was characterized from Hypericum ascyron. The architecture contains a caryophyllane-type moiety and a C(6) unit derived from polyprenylated acylphloroglucinols. Its structure and absolute configuration were determined by comprehensive spectroscopic and X-ray diffraction data. Biologically, compound 1 inhibited cell proliferation in LoVo, SW480, and HCT116 cell lines (IC(50) = 12.30–24.57 µM). GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00362-z. Springer Nature Singapore 2022-11-07 /pmc/articles/PMC9640506/ /pubmed/36342546 http://dx.doi.org/10.1007/s13659-022-00362-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Hu, Ya-Li
Li, Xing-Ren
Xu, Gang
Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron
title Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron
title_full Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron
title_fullStr Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron
title_full_unstemmed Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron
title_short Carascynol A, a hybrid of caryophyllane-type terpenoid and a C(6) unit degraded by polyprenylated acylphloroglucinols from Hypericum ascyron
title_sort carascynol a, a hybrid of caryophyllane-type terpenoid and a c(6) unit degraded by polyprenylated acylphloroglucinols from hypericum ascyron
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640506/
https://www.ncbi.nlm.nih.gov/pubmed/36342546
http://dx.doi.org/10.1007/s13659-022-00362-z
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