Cargando…
NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients
NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project’s goal is to develop an open imaging...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640522/ https://www.ncbi.nlm.nih.gov/pubmed/36344838 http://dx.doi.org/10.1186/s41747-022-00306-9 |
_version_ | 1784825865273606144 |
---|---|
author | Borgheresi, Rita Barucci, Andrea Colantonio, Sara Aghakhanyan, Gayane Assante, Massimiliano Bertelli, Elena Carlini, Emanuele Carpi, Roberto Caudai, Claudia Cavallero, Diletta Cioni, Dania Cirillo, Roberto Colcelli, Valentina Dell’Amico, Andrea Di Gangi, Domnico Erba, Paola Anna Faggioni, Lorenzo Falaschi, Zeno Gabelloni, Michela Gini, Rosa Lelii, Lucio Liò, Pietro Lorito, Antonio Lucarini, Silvia Manghi, Paolo Mangiacrapa, Francesco Marzi, Chiara Mazzei, Maria Antonietta Mercatelli, Laura Mirabile, Antonella Mungai, Francesco Miele, Vittorio Olmastroni, Maristella Pagano, Pasquale Paiar, Fabiola Panichi, Giancarlo Pascali, Maria Antonietta Pasquinelli, Filippo Shortrede, Jorge Eduardo Tumminello, Lorenzo Volterrani, Luca Neri, Emanuele |
author_facet | Borgheresi, Rita Barucci, Andrea Colantonio, Sara Aghakhanyan, Gayane Assante, Massimiliano Bertelli, Elena Carlini, Emanuele Carpi, Roberto Caudai, Claudia Cavallero, Diletta Cioni, Dania Cirillo, Roberto Colcelli, Valentina Dell’Amico, Andrea Di Gangi, Domnico Erba, Paola Anna Faggioni, Lorenzo Falaschi, Zeno Gabelloni, Michela Gini, Rosa Lelii, Lucio Liò, Pietro Lorito, Antonio Lucarini, Silvia Manghi, Paolo Mangiacrapa, Francesco Marzi, Chiara Mazzei, Maria Antonietta Mercatelli, Laura Mirabile, Antonella Mungai, Francesco Miele, Vittorio Olmastroni, Maristella Pagano, Pasquale Paiar, Fabiola Panichi, Giancarlo Pascali, Maria Antonietta Pasquinelli, Filippo Shortrede, Jorge Eduardo Tumminello, Lorenzo Volterrani, Luca Neri, Emanuele |
author_sort | Borgheresi, Rita |
collection | PubMed |
description | NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project’s goal is to develop an open imaging biobank for the collection and preservation of a large amount of standardised imaging multimodal datasets, including computed tomography, magnetic resonance imaging, and positron emission tomography data, together with the corresponding patient-related and omics-related relevant information extracted from regional healthcare services using an adapted privacy-preserving model. The project is based on an open-source imaging biobank and an open-science oriented virtual research environment (VRE). Available integrative omics and multi-imaging data of three use cases (prostate cancer, rectal cancer, and gastric cancer) will be collected. All data confined in NAVIGATOR (i.e., standard and novel imaging biomarkers, non-imaging data, health agency data) will be used to create a digital patient model, to support the reliable prediction of the disease phenotype and risk stratification. The VRE that relies on a well-established infrastructure, called D4Science.org, will further provide a multiset infrastructure for processing the integrative omics data, extracting specific radiomic signatures, and for identification and testing of novel imaging biomarkers through big data analytics and artificial intelligence. |
format | Online Article Text |
id | pubmed-9640522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-96405222022-11-15 NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients Borgheresi, Rita Barucci, Andrea Colantonio, Sara Aghakhanyan, Gayane Assante, Massimiliano Bertelli, Elena Carlini, Emanuele Carpi, Roberto Caudai, Claudia Cavallero, Diletta Cioni, Dania Cirillo, Roberto Colcelli, Valentina Dell’Amico, Andrea Di Gangi, Domnico Erba, Paola Anna Faggioni, Lorenzo Falaschi, Zeno Gabelloni, Michela Gini, Rosa Lelii, Lucio Liò, Pietro Lorito, Antonio Lucarini, Silvia Manghi, Paolo Mangiacrapa, Francesco Marzi, Chiara Mazzei, Maria Antonietta Mercatelli, Laura Mirabile, Antonella Mungai, Francesco Miele, Vittorio Olmastroni, Maristella Pagano, Pasquale Paiar, Fabiola Panichi, Giancarlo Pascali, Maria Antonietta Pasquinelli, Filippo Shortrede, Jorge Eduardo Tumminello, Lorenzo Volterrani, Luca Neri, Emanuele Eur Radiol Exp Guideline/Position paper NAVIGATOR is an Italian regional project boosting precision medicine in oncology with the aim of making it more predictive, preventive, and personalised by advancing translational research based on quantitative imaging and integrative omics analyses. The project’s goal is to develop an open imaging biobank for the collection and preservation of a large amount of standardised imaging multimodal datasets, including computed tomography, magnetic resonance imaging, and positron emission tomography data, together with the corresponding patient-related and omics-related relevant information extracted from regional healthcare services using an adapted privacy-preserving model. The project is based on an open-source imaging biobank and an open-science oriented virtual research environment (VRE). Available integrative omics and multi-imaging data of three use cases (prostate cancer, rectal cancer, and gastric cancer) will be collected. All data confined in NAVIGATOR (i.e., standard and novel imaging biomarkers, non-imaging data, health agency data) will be used to create a digital patient model, to support the reliable prediction of the disease phenotype and risk stratification. The VRE that relies on a well-established infrastructure, called D4Science.org, will further provide a multiset infrastructure for processing the integrative omics data, extracting specific radiomic signatures, and for identification and testing of novel imaging biomarkers through big data analytics and artificial intelligence. Springer Vienna 2022-11-08 /pmc/articles/PMC9640522/ /pubmed/36344838 http://dx.doi.org/10.1186/s41747-022-00306-9 Text en © The Author(s) under exclusive licence to European Society of Radiology 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Guideline/Position paper Borgheresi, Rita Barucci, Andrea Colantonio, Sara Aghakhanyan, Gayane Assante, Massimiliano Bertelli, Elena Carlini, Emanuele Carpi, Roberto Caudai, Claudia Cavallero, Diletta Cioni, Dania Cirillo, Roberto Colcelli, Valentina Dell’Amico, Andrea Di Gangi, Domnico Erba, Paola Anna Faggioni, Lorenzo Falaschi, Zeno Gabelloni, Michela Gini, Rosa Lelii, Lucio Liò, Pietro Lorito, Antonio Lucarini, Silvia Manghi, Paolo Mangiacrapa, Francesco Marzi, Chiara Mazzei, Maria Antonietta Mercatelli, Laura Mirabile, Antonella Mungai, Francesco Miele, Vittorio Olmastroni, Maristella Pagano, Pasquale Paiar, Fabiola Panichi, Giancarlo Pascali, Maria Antonietta Pasquinelli, Filippo Shortrede, Jorge Eduardo Tumminello, Lorenzo Volterrani, Luca Neri, Emanuele NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients |
title | NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients |
title_full | NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients |
title_fullStr | NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients |
title_full_unstemmed | NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients |
title_short | NAVIGATOR: an Italian regional imaging biobank to promote precision medicine for oncologic patients |
title_sort | navigator: an italian regional imaging biobank to promote precision medicine for oncologic patients |
topic | Guideline/Position paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640522/ https://www.ncbi.nlm.nih.gov/pubmed/36344838 http://dx.doi.org/10.1186/s41747-022-00306-9 |
work_keys_str_mv | AT borgheresirita navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT barucciandrea navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT colantoniosara navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT aghakhanyangayane navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT assantemassimiliano navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT bertellielena navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT carliniemanuele navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT carpiroberto navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT caudaiclaudia navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT cavallerodiletta navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT cionidania navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT cirilloroberto navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT colcellivalentina navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT dellamicoandrea navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT digangidomnico navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT erbapaolaanna navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT faggionilorenzo navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT falaschizeno navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT gabellonimichela navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT ginirosa navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT leliilucio navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT liopietro navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT loritoantonio navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT lucarinisilvia navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT manghipaolo navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT mangiacrapafrancesco navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT marzichiara navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT mazzeimariaantonietta navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT mercatellilaura navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT mirabileantonella navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT mungaifrancesco navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT mielevittorio navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT olmastronimaristella navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT paganopasquale navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT paiarfabiola navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT panichigiancarlo navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT pascalimariaantonietta navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT pasquinellifilippo navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT shortredejorgeeduardo navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT tumminellolorenzo navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT volterraniluca navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT neriemanuele navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients AT navigatoranitalianregionalimagingbiobanktopromoteprecisionmedicineforoncologicpatients |