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Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that specific mtDNA damage leads to an exacerbated mtDNA turnover, independent of canonical macroautophagy, but relying on lysosom...

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Detalles Bibliográficos
Autores principales:	Sen, Ayesha, Kallabis, Sebastian, Gaedke, Felix, Jüngst, Christian, Boix, Julia, Nüchel, Julian, Maliphol, Kanjanamas, Hofmann, Julia, Schauss, Astrid C., Krüger, Marcus, Wiesner, Rudolf J., Pla-Martín, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640553/ https://www.ncbi.nlm.nih.gov/pubmed/36344526 http://dx.doi.org/10.1038/s41467-022-34205-9

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