Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51

Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are considered to form through homologous recombination (HR). Indeed, SCE induction upon irradiation requires the canonical HR factors BRCA1, BRCA2 and RAD51. In contrast, replication-blocking agents, including PARP...

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Detalles Bibliográficos
Autores principales: Heijink, Anne Margriet, Stok, Colin, Porubsky, David, Manolika, Eleni Maria, de Kanter, Jurrian K., Kok, Yannick P., Everts, Marieke, de Boer, H. Rudolf, Audrey, Anastasia, Bakker, Femke J., Wierenga, Elles, Tijsterman, Marcel, Guryev, Victor, Spierings, Diana C. J., Knipscheer, Puck, van Boxtel, Ruben, Ray Chaudhuri, Arnab, Lansdorp, Peter M., van Vugt, Marcel A. T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640580/
https://www.ncbi.nlm.nih.gov/pubmed/36344511
http://dx.doi.org/10.1038/s41467-022-34519-8

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