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An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis

Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in PAH, combining natural and induced bone morphogenetic protein...

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Detalles Bibliográficos
Autores principales:	Ainscough, Alexander J., Smith, Timothy J., Haensel, Maike, Rhodes, Christopher J., Fellows, Adam, Whitwell, Harry J., Vasilaki, Eleni, Gray, Kelly, Freeman, Adrian, Howard, Luke S., Wharton, John, Dunmore, Benjamin, Upton, Paul D., Wilkins, Martin R., Edel, Joshua B., Wojciak-Stothard, Beata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640600/ https://www.ncbi.nlm.nih.gov/pubmed/36344664 http://dx.doi.org/10.1038/s42003-022-04169-z

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