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Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy

The purpose of this study was to identify how chronic hypertension (HTN) and hypertensive retinopathy (HTNR) have different effects on retinal damage including inner retinal thinning and microvasculature impairment. The subjects were divided into three groups: controls, HTN patients without HTNR (HT...

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Autores principales: Nam, Ki-Yup, Lee, Min-Woo, Jun, Ji-Ho, Sung, Jae-Yun, Kim, Jung-Yeul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640608/
https://www.ncbi.nlm.nih.gov/pubmed/36344638
http://dx.doi.org/10.1038/s41598-022-23756-y
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author Nam, Ki-Yup
Lee, Min-Woo
Jun, Ji-Ho
Sung, Jae-Yun
Kim, Jung-Yeul
author_facet Nam, Ki-Yup
Lee, Min-Woo
Jun, Ji-Ho
Sung, Jae-Yun
Kim, Jung-Yeul
author_sort Nam, Ki-Yup
collection PubMed
description The purpose of this study was to identify how chronic hypertension (HTN) and hypertensive retinopathy (HTNR) have different effects on retinal damage including inner retinal thinning and microvasculature impairment. The subjects were divided into three groups: controls, HTN patients without HTNR (HTN group), and patients with relieved HTNR (HTNR group). The ganglion cell-inner plexiform layer (GC-IPL) thickness, vessel density (VD), and GC-IPL/VD ratio were compared among the groups. A total of 241 eyes were enrolled; 101 in the control group, 92 in the HTN group, and 48 in the HTNR group. The mean GC-IPL thicknesses were 83.5 ± 5.7, 82.1 ± 6.2, and 75.9 ± 10.7 μm in each group, respectively (P < 0.001). The VD was 20.5 ± 1.3, 19.6 ± 1.4, and 19.5 ± 1.6 mm(−1) in each group, respectively (P = 0.001). The GC-IPL/VD ratio was 4.10 ± 0.33, 4.20 ± 0.40, and 3.88 ± 0.56 in each group, respectively (P < 0.001). In the HTNR group, HTN duration (B = 0.054, P = 0.013) and systolic blood pressure (SBP) (B = −0.012, P = 0.004) were significantly associated with the GC-IPL/VD ratio. In conclusion, inner retinal reduction and retinal microvasculature impairment were observed in patients with HTN and HTNR, and the GC-IPL/VD ratio of HTNR patients was significantly lower than that of HTN patients, indicating more prominent damage to the inner retina than microvasculature in HTNR patients. Additionally, the GC-IPL/VD ratio was significantly associated with SBP in HTNR patients, so more strict BP control is required in HTNR patients.
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spelling pubmed-96406082022-11-15 Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy Nam, Ki-Yup Lee, Min-Woo Jun, Ji-Ho Sung, Jae-Yun Kim, Jung-Yeul Sci Rep Article The purpose of this study was to identify how chronic hypertension (HTN) and hypertensive retinopathy (HTNR) have different effects on retinal damage including inner retinal thinning and microvasculature impairment. The subjects were divided into three groups: controls, HTN patients without HTNR (HTN group), and patients with relieved HTNR (HTNR group). The ganglion cell-inner plexiform layer (GC-IPL) thickness, vessel density (VD), and GC-IPL/VD ratio were compared among the groups. A total of 241 eyes were enrolled; 101 in the control group, 92 in the HTN group, and 48 in the HTNR group. The mean GC-IPL thicknesses were 83.5 ± 5.7, 82.1 ± 6.2, and 75.9 ± 10.7 μm in each group, respectively (P < 0.001). The VD was 20.5 ± 1.3, 19.6 ± 1.4, and 19.5 ± 1.6 mm(−1) in each group, respectively (P = 0.001). The GC-IPL/VD ratio was 4.10 ± 0.33, 4.20 ± 0.40, and 3.88 ± 0.56 in each group, respectively (P < 0.001). In the HTNR group, HTN duration (B = 0.054, P = 0.013) and systolic blood pressure (SBP) (B = −0.012, P = 0.004) were significantly associated with the GC-IPL/VD ratio. In conclusion, inner retinal reduction and retinal microvasculature impairment were observed in patients with HTN and HTNR, and the GC-IPL/VD ratio of HTNR patients was significantly lower than that of HTN patients, indicating more prominent damage to the inner retina than microvasculature in HTNR patients. Additionally, the GC-IPL/VD ratio was significantly associated with SBP in HTNR patients, so more strict BP control is required in HTNR patients. Nature Publishing Group UK 2022-11-07 /pmc/articles/PMC9640608/ /pubmed/36344638 http://dx.doi.org/10.1038/s41598-022-23756-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nam, Ki-Yup
Lee, Min-Woo
Jun, Ji-Ho
Sung, Jae-Yun
Kim, Jung-Yeul
Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
title Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
title_full Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
title_fullStr Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
title_full_unstemmed Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
title_short Different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
title_sort different characteristics of retinal damage between chronic hypertension and hypertensive retinopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640608/
https://www.ncbi.nlm.nih.gov/pubmed/36344638
http://dx.doi.org/10.1038/s41598-022-23756-y
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