Cargando…

CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy

Osteoarthritis (OA) is a degenerative joint disorder causing pain and functional disability. Emerging evidence reveals that circular RNAs (circRNAs) play essential roles in OA progression and development. This study aimed to investigate the role of a novel circRNA factor, circFOXO3, in the progressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Chen, Li, Xiaodong, Sun, Guantong, Liu, Pengcheng, Kong, Keyu, Chen, Xuzhuo, Yang, Fei, Wang, Xiaoqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640610/ https://www.ncbi.nlm.nih.gov/pubmed/36344492 http://dx.doi.org/10.1038/s41419-022-05390-8

Ejemplares similares

The Emerging Roles of circFOXO3 in Cancer
por: Rao, Dean, et al.
Publicado: (2021)

CircFOXO3 rs12196996, a polymorphism at the gene flanking intron, is associated with circFOXO3 levels and the risk of coronary artery disease
por: Zhou, Yu-Lan, et al.
Publicado: (2020)

Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulating PI3K/Akt Pathway
por: Liu, Siyu, et al.
Publicado: (2022)

Pathogenic mechanisms and the potential clinical value of circFoxo3 in cancers
por: Zhang, Lei, et al.
Publicado: (2021)

Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice
por: Zhou, Lei, et al.
Publicado: (2021)

Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR‐29a‐3p
por: Kong, Zhe, et al.
Publicado: (2019)

Circular RNA circFOXO3 regulates KDM2A by targeting miR‐214 to promote tumor growth and metastasis in oral squamous cell carcinoma
por: Ai, Yilong, et al.
Publicado: (2021)

CircFoxo3 Promotes Adriamycin Resistance Through Regulation of miR-199a-5p/ATP Binding Cassette Subfamily C Member 1 Axis in Hepatocellular Carcinoma
por: Huang, Wei, et al.
Publicado: (2020)

Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients
por: Zhou, Jiao, et al.
Publicado: (2019)

Eugenol-Induced Autophagy and Apoptosis in Breast Cancer Cells via PI3K/AKT/FOXO3a Pathway Inhibition
por: Abdullah, Mashan L., et al.
Publicado: (2021)

circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through Sponging miR-29a-3p and miR-122-5p
por: Yang, Fafen, et al.
Publicado: (2022)

Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway
por: Tao, Ting, et al.
Publicado: (2021)

Eldecalcitol prevents muscle loss by suppressing PI3K/AKT/FOXOs pathway in orchiectomized mice
por: Zhang, Haichao, et al.
Publicado: (2022)

Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway
por: Chen, Yuxi, et al.
Publicado: (2020)

Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway
por: Zhang, Xinling, et al.
Publicado: (2017)

Downregulation of circ-Foxo3 in breast cancer stem-like cells
por: Kamalabadi-Farahani, Mohammad, et al.
Publicado: (2023)

miR-3682-3p directly targets FOXO3 and stimulates tumor stemness in hepatocellular carcinoma via a positive feedback loop involving FOXO3/PI3K/AKT/c-Myc
por: Chen, Qian, et al.
Publicado: (2022)

Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis
por: Lv, Wang, et al.
Publicado: (2022)

Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation
por: Li, Xiaoyue, et al.
Publicado: (2019)

IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
por: Duan, Shiyu, et al.
Publicado: (2018)

Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
por: Frankum, Ryan, et al.
Publicado: (2021)

Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation
por: Cohen, Shenhav, et al.
Publicado: (2014)

The role of AKT and FOXO3 in preventing ovarian toxicity induced by cyclophosphamide
por: Zhang, Bao-fang, et al.
Publicado: (2018)

FOXO3 induces ubiquitylation of AKT through MUL1 regulation
por: Kim, Sun-Yong, et al.
Publicado: (2017)

Anaphylatoxins Activate Ca(2+), Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium
por: Busch, Catharina, et al.
Publicado: (2017)

FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development
por: Luu, Thuy T., et al.
Publicado: (2022)

Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines
por: Nozhat, Zahra, et al.
Publicado: (2018)

Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma
por: Li, Yuehua, et al.
Publicado: (2021)

FKBP5 Exacerbates Impairments in Cerebral Ischemic Stroke by Inducing Autophagy via the AKT/FOXO3 Pathway
por: Yu, Shijia, et al.
Publicado: (2020)

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
por: Merkenschlager, Matthias, et al.
Publicado: (2010)

Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-κB/MAPK signaling
por: Zhao, Chen, et al.
Publicado: (2023)

Correction to: Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
por: Frankum, Ryan, et al.
Publicado: (2021)

Treponema pallidum membrane protein Tp47 induced autophagy and inhibited cell migration in HMC3 cells via the PI3K/AKT/FOXO1 pathway
por: Xie, Lin, et al.
Publicado: (2023)

Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion
por: Yang, Zhenguo, et al.
Publicado: (2022)

Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer
por: Das, T P, et al.
Publicado: (2016)

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro
por: Li, Jun, et al.
Publicado: (2019)

Correction: The role of AKT and FOXO3 in preventing ovarian toxicity induced by cyclophosphamide
por: Zhang, Bao-fang, et al.
Publicado: (2019)

Homocysteine promotes cardiac fibrosis by regulating the Akt/FoxO3 pathway
por: Shi, Ying, et al.
Publicado: (2021)

Mitochondria and FOXO3: breath or die
por: Hagenbuchner, Judith, et al.
Publicado: (2013)

The Role of Foxo3 in Leydig Cells
por: Choi, Young Suk, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6jeplv9cfrmr5moerl49kv4g3u