EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis

EGFR phosphorylation is required for TLR4-mediated macrophage activation during sepsis. However, whether and how intracellular EGFR is transported during endotoxemia have largely been unknown. Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two diff...

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Detalles Bibliográficos
Autores principales: Zhang, Xuedi, Chen, Cuiping, Ling, Chunxiu, Luo, Shuhua, Xiong, Ziying, Liu, Xiaolei, Liao, Chaoxiong, Xie, Pengyun, Liu, Youtan, Zhang, Liangqing, Chen, Zhanghui, Liu, Zhifeng, Tang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640671/
https://www.ncbi.nlm.nih.gov/pubmed/36344490
http://dx.doi.org/10.1038/s41419-022-05370-y

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