Necroptosis-mediated HMGB1 secretion of keratinocytes as a key step for inflammation development in contact hypersensitivity

Keratinocyte necroptosis (with proinflammatory characteristic) is required for epidermal damage in contact hypersensitivity (CHS). In DNCB-induced CHS mice model, we observed the aggravated keratinocyte death and increased phosphorylation level of MLKL, RIPK3 and RIPK1. However, CHS skin lesion did...

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Detalles Bibliográficos
Autores principales: Lian, Ni, Chen, Yujie, Chen, Sihan, Xiao, Ta, Song, Changjun, Ke, Yangying, Wei, Xuecui, Gong, Chunyan, Yu, Hui, Gu, Heng, Chen, Qing, Li, Min, Chen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640721/
https://www.ncbi.nlm.nih.gov/pubmed/36344541
http://dx.doi.org/10.1038/s41420-022-01228-6

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