Analysis of matched primary and recurrent BRCA1/2 mutation-associated tumors identifies recurrence-specific drivers

Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). Herein we perform multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify potential recurrence-specific drivers. PARP1 ampl...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Jennifer B., Pueschl, Dana, Wubbenhorst, Bradley, Fan, Mengyao, Pluta, John, D’Andrea, Kurt, Hubert, Anna P., Shilan, Jake S., Zhou, Wenting, Kraya, Adam A., Llop Guevara, Alba, Ruan, Catherine, Serra, Violeta, Balmaña, Judith, Feldman, Michael, Morin, Pat J., Nayak, Anupma, Maxwell, Kara N., Domchek, Susan M., Nathanson, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640723/
https://www.ncbi.nlm.nih.gov/pubmed/36344544
http://dx.doi.org/10.1038/s41467-022-34523-y

Ejemplares similares

Ejemplares similares