Cargando…

Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study

Ecological studies have suggested the protective effect of micro-dose lithium in drinking water against suicide, however, the association between body lithium level and suicide is unknown. We aimed to compare body lithium levels between suicide and non-suicide fatalities. This cross-sectional study...

Descripción completa

Detalles Bibliográficos
Autores principales: Ando, Shuntaro, Suzuki, Hideto, Matsukawa, Takehisa, Usami, Satoshi, Muramatsu, Hisanori, Fukunaga, Tatsushige, Yokoyama, Kazuhito, Okazaki, Yuji, Nishida, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640730/
https://www.ncbi.nlm.nih.gov/pubmed/36344516
http://dx.doi.org/10.1038/s41398-022-02238-9
_version_ 1784825925345476608
author Ando, Shuntaro
Suzuki, Hideto
Matsukawa, Takehisa
Usami, Satoshi
Muramatsu, Hisanori
Fukunaga, Tatsushige
Yokoyama, Kazuhito
Okazaki, Yuji
Nishida, Atsushi
author_facet Ando, Shuntaro
Suzuki, Hideto
Matsukawa, Takehisa
Usami, Satoshi
Muramatsu, Hisanori
Fukunaga, Tatsushige
Yokoyama, Kazuhito
Okazaki, Yuji
Nishida, Atsushi
author_sort Ando, Shuntaro
collection PubMed
description Ecological studies have suggested the protective effect of micro-dose lithium in drinking water against suicide, however, the association between body lithium level and suicide is unknown. We aimed to compare body lithium levels between suicide and non-suicide fatalities. This cross-sectional study included 12 suicides and 16 non-suicides who were examined or dissected at the Tokyo Medical Examiner’s Office from March 2018 to June 2021. The aqueous humor lithium concentration was measured twice using inductively coupled plasma mass spectrometry. Analysis of covariance (ANCOVA) was used to compare the lithium concentration between suicides and non-suicides. Mixed-effects model was conducted to account for all lithium concentration data. The aqueous humor lithium concentration did not change after death (t(7) = −0.70, [Formula: see text] , SE = 0.03, 95% CI = [−0.09, 0.05], P = 0.51, Cohen’s d = 0.01). The aqueous humor lithium concentration was lower in suicides (mean 0.50 μg/L (variance s(2) 0.04)) than in non-suicides (mean 0.92 μg/L (s(2) 0.07)) (t(26) = 4.47, [Formula: see text] , SE = 0.09, 95% CI = [0.22 to 0.61], P < 0.001, Cohen’s d = 1.71). The ANCOVA showed that death by suicide was significantly associated with lower lithium concentration (F(1, 24) = 8.57, P = 0.007), and the effect size was large (η(p)(2) = 0.26). The random intercept model showed a significant effect of suicide on aqueous humor lithium concentration (b = −0.261, SE = 0.102, 95% CI = [−0.471 to −0.051], t(24) = −2.568, P = 0.017). The results of this study demonstrate that even micro-dose lithium is associated with suicide death. Clinical studies are warranted to examine the effects of micro-dose lithium on suicide prevention.
format Online
Article
Text
id pubmed-9640730
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-96407302022-11-15 Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study Ando, Shuntaro Suzuki, Hideto Matsukawa, Takehisa Usami, Satoshi Muramatsu, Hisanori Fukunaga, Tatsushige Yokoyama, Kazuhito Okazaki, Yuji Nishida, Atsushi Transl Psychiatry Article Ecological studies have suggested the protective effect of micro-dose lithium in drinking water against suicide, however, the association between body lithium level and suicide is unknown. We aimed to compare body lithium levels between suicide and non-suicide fatalities. This cross-sectional study included 12 suicides and 16 non-suicides who were examined or dissected at the Tokyo Medical Examiner’s Office from March 2018 to June 2021. The aqueous humor lithium concentration was measured twice using inductively coupled plasma mass spectrometry. Analysis of covariance (ANCOVA) was used to compare the lithium concentration between suicides and non-suicides. Mixed-effects model was conducted to account for all lithium concentration data. The aqueous humor lithium concentration did not change after death (t(7) = −0.70, [Formula: see text] , SE = 0.03, 95% CI = [−0.09, 0.05], P = 0.51, Cohen’s d = 0.01). The aqueous humor lithium concentration was lower in suicides (mean 0.50 μg/L (variance s(2) 0.04)) than in non-suicides (mean 0.92 μg/L (s(2) 0.07)) (t(26) = 4.47, [Formula: see text] , SE = 0.09, 95% CI = [0.22 to 0.61], P < 0.001, Cohen’s d = 1.71). The ANCOVA showed that death by suicide was significantly associated with lower lithium concentration (F(1, 24) = 8.57, P = 0.007), and the effect size was large (η(p)(2) = 0.26). The random intercept model showed a significant effect of suicide on aqueous humor lithium concentration (b = −0.261, SE = 0.102, 95% CI = [−0.471 to −0.051], t(24) = −2.568, P = 0.017). The results of this study demonstrate that even micro-dose lithium is associated with suicide death. Clinical studies are warranted to examine the effects of micro-dose lithium on suicide prevention. Nature Publishing Group UK 2022-11-07 /pmc/articles/PMC9640730/ /pubmed/36344516 http://dx.doi.org/10.1038/s41398-022-02238-9 Text en © The Author(s) 2022, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ando, Shuntaro
Suzuki, Hideto
Matsukawa, Takehisa
Usami, Satoshi
Muramatsu, Hisanori
Fukunaga, Tatsushige
Yokoyama, Kazuhito
Okazaki, Yuji
Nishida, Atsushi
Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
title Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
title_full Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
title_fullStr Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
title_full_unstemmed Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
title_short Comparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
title_sort comparison of lithium levels between suicide and non-suicide fatalities: cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640730/
https://www.ncbi.nlm.nih.gov/pubmed/36344516
http://dx.doi.org/10.1038/s41398-022-02238-9
work_keys_str_mv AT andoshuntaro comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT suzukihideto comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT matsukawatakehisa comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT usamisatoshi comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT muramatsuhisanori comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT fukunagatatsushige comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT yokoyamakazuhito comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT okazakiyuji comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy
AT nishidaatsushi comparisonoflithiumlevelsbetweensuicideandnonsuicidefatalitiescrosssectionalstudy