Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

BACKGROUND: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-ind...

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Autores principales: Maitre, Thomas, Bonnet, Maryline, Calmy, Alexandra, Raberahona, Mihaja, Rakotoarivelo, Rivonirina Andry, Rakotosamimanana, Niaina, Ambrosioni, Juan, Miró, José M., Debeaudrap, Pierre, Muzoora, Conrad, Davis, Angharad, Meintjes, Graeme, Wasserman, Sean, Wilkinson, Robert, Eholié, Serge, Nogbou, Frédéric Ello, Calvo-Cortes, Maria-Camilla, Chazallon, Corine, Machault, Vanessa, Anglaret, Xavier, Bonnet, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640846/
https://www.ncbi.nlm.nih.gov/pubmed/36348453
http://dx.doi.org/10.1186/s13063-022-06772-1

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