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Metformin promotes in vitro maturation of oocytes from aged mice by attenuating mitochondrial oxidative stress via SIRT3-dependent SOD2ac

Human female fecundity decreases irreversibly as chronological age rises, adversely affecting oocyte quality, consequently worsening pregnancy outcomes and increasing the extent of birth defects. The first-line type 2 diabetes treatment metformin has been associated with delayed aging and reduction...

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Detalles Bibliográficos
Autores principales:	Cao, Yongzhi, Wang, Zhao, Zhang, Changming, Bian, Yuehong, Zhang, Xin, Liu, Xin, Chen, Wendi, Zhao, Yueran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9640937/ https://www.ncbi.nlm.nih.gov/pubmed/36393869 http://dx.doi.org/10.3389/fcell.2022.1028510

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