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Nrf2: An all-rounder in depression
The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once disrupted, it can lead to various pathological outcomes and diseases, such as depression. Oxidative stress can result in or aggravate a battery of pathological processes including mitochondrial dysfunction, ne...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641011/ https://www.ncbi.nlm.nih.gov/pubmed/36335763 http://dx.doi.org/10.1016/j.redox.2022.102522 |
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author | Zuo, Chengchao Cao, Huan Song, Yu Gu, Zhongya Huang, Yaqi Yang, Yuyan Miao, Jinfeng Zhu, Liudi Chen, Jianguo Jiang, Yongsheng Wang, Furong |
author_facet | Zuo, Chengchao Cao, Huan Song, Yu Gu, Zhongya Huang, Yaqi Yang, Yuyan Miao, Jinfeng Zhu, Liudi Chen, Jianguo Jiang, Yongsheng Wang, Furong |
author_sort | Zuo, Chengchao |
collection | PubMed |
description | The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once disrupted, it can lead to various pathological outcomes and diseases, such as depression. Oxidative stress can result in or aggravate a battery of pathological processes including mitochondrial dysfunction, neuroinflammation, autophagical disorder and ferroptosis, which have been found to be involved in the development of depression. Inhibition of oxidative stress and related pathological processes can help improve depression. In this regard, the nuclear factor erythroid 2-related factor 2 (Nrf2) in the antioxidant defense system may play a pivotal role. Nrf2 activation can not only regulate the expression of a series of antioxidant genes that reduce oxidative stress and its damages, but also directly regulate the genes related to the above pathological processes to combat the corresponding alterations. Therefore, targeting Nrf2 has great potential for the treatment of depression. Activation of Nrf2 has antidepressant effect, but the specific mechanism remains to be elucidated. This article reviews the key role of Nrf2 in depression, focusing on the possible mechanisms of Nrf2 regulating oxidative stress and related pathological processes in depression treatment. Meanwhile, we summarize some natural and synthetic compounds targeting Nrf2 in depression therapy. All the above may provide new insights into targeting Nrf2 for the treatment of depression and provide a broad basis for clinical transformation. |
format | Online Article Text |
id | pubmed-9641011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96410112022-11-15 Nrf2: An all-rounder in depression Zuo, Chengchao Cao, Huan Song, Yu Gu, Zhongya Huang, Yaqi Yang, Yuyan Miao, Jinfeng Zhu, Liudi Chen, Jianguo Jiang, Yongsheng Wang, Furong Redox Biol Review Article The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once disrupted, it can lead to various pathological outcomes and diseases, such as depression. Oxidative stress can result in or aggravate a battery of pathological processes including mitochondrial dysfunction, neuroinflammation, autophagical disorder and ferroptosis, which have been found to be involved in the development of depression. Inhibition of oxidative stress and related pathological processes can help improve depression. In this regard, the nuclear factor erythroid 2-related factor 2 (Nrf2) in the antioxidant defense system may play a pivotal role. Nrf2 activation can not only regulate the expression of a series of antioxidant genes that reduce oxidative stress and its damages, but also directly regulate the genes related to the above pathological processes to combat the corresponding alterations. Therefore, targeting Nrf2 has great potential for the treatment of depression. Activation of Nrf2 has antidepressant effect, but the specific mechanism remains to be elucidated. This article reviews the key role of Nrf2 in depression, focusing on the possible mechanisms of Nrf2 regulating oxidative stress and related pathological processes in depression treatment. Meanwhile, we summarize some natural and synthetic compounds targeting Nrf2 in depression therapy. All the above may provide new insights into targeting Nrf2 for the treatment of depression and provide a broad basis for clinical transformation. Elsevier 2022-10-31 /pmc/articles/PMC9641011/ /pubmed/36335763 http://dx.doi.org/10.1016/j.redox.2022.102522 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Zuo, Chengchao Cao, Huan Song, Yu Gu, Zhongya Huang, Yaqi Yang, Yuyan Miao, Jinfeng Zhu, Liudi Chen, Jianguo Jiang, Yongsheng Wang, Furong Nrf2: An all-rounder in depression |
title | Nrf2: An all-rounder in depression |
title_full | Nrf2: An all-rounder in depression |
title_fullStr | Nrf2: An all-rounder in depression |
title_full_unstemmed | Nrf2: An all-rounder in depression |
title_short | Nrf2: An all-rounder in depression |
title_sort | nrf2: an all-rounder in depression |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641011/ https://www.ncbi.nlm.nih.gov/pubmed/36335763 http://dx.doi.org/10.1016/j.redox.2022.102522 |
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