Bidirectional regulation between tumor cell-intrinsic PD-L1 and TGF-β1 in epithelial-to-mesenchymal transition in melanoma

BACKGROUND: Transforming growth factor-β1 (TGF-β1) is the predominant form of TGF-β and induces epithelial-to-mesenchymal transition (EMT) in melanoma. Tumor cell-intrinsic programmed death ligand-1 (PD-L1) plays a crucial role in maintenance of the EMT in melanoma. However, the relationship among t...

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Detalles Bibliográficos
Autores principales: Li, Zhen, Wang, Fengdi, Dang, Jianzhong, Cheng, Fanjun, Zheng, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641118/
https://www.ncbi.nlm.nih.gov/pubmed/36388018
http://dx.doi.org/10.21037/tcr-22-292

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