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Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology. Numerous motor proteins, many of which are involved in synaptic transmission, mediate transport in neurons. Dysfunction in moto...

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Detalles Bibliográficos
Autores principales:	Selvarasu, Karthikeyan, Singh, Abhay Kumar, Iyaswamy, Ashok, Gopalkrishnashetty Sreenivasmurthy, Sravan, Krishnamoorthi, Senthilkumar, Bera, Amal Kanti, Huang, Jian-Dong, Durairajan, Siva Sundara Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641281/ https://www.ncbi.nlm.nih.gov/pubmed/36387285 http://dx.doi.org/10.3389/fmolb.2022.1050768

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