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A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal

BACKGROUND: Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dys...

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Autores principales: De la Peña-Arteaga, Víctor, Morgado, Pedro, Couto, Beatriz, Ferreira, Sónia, Castro, Inês, Sousa, Nuno, Soriano-Mas, Carles, Picó-Pérez, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641649/
https://www.ncbi.nlm.nih.gov/pubmed/36184890
http://dx.doi.org/10.1192/j.eurpsy.2022.2322
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author De la Peña-Arteaga, Víctor
Morgado, Pedro
Couto, Beatriz
Ferreira, Sónia
Castro, Inês
Sousa, Nuno
Soriano-Mas, Carles
Picó-Pérez, Maria
author_facet De la Peña-Arteaga, Víctor
Morgado, Pedro
Couto, Beatriz
Ferreira, Sónia
Castro, Inês
Sousa, Nuno
Soriano-Mas, Carles
Picó-Pérez, Maria
author_sort De la Peña-Arteaga, Víctor
collection PubMed
description BACKGROUND: Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD. METHODS: Adult patients with OCD (n = 31) and healthy controls (HC; n = 30) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored. RESULTS: Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network. CONCLUSIONS: The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective.
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spelling pubmed-96416492022-11-18 A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal De la Peña-Arteaga, Víctor Morgado, Pedro Couto, Beatriz Ferreira, Sónia Castro, Inês Sousa, Nuno Soriano-Mas, Carles Picó-Pérez, Maria Eur Psychiatry Research Article BACKGROUND: Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD. METHODS: Adult patients with OCD (n = 31) and healthy controls (HC; n = 30) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored. RESULTS: Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network. CONCLUSIONS: The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective. Cambridge University Press 2022-10-03 /pmc/articles/PMC9641649/ /pubmed/36184890 http://dx.doi.org/10.1192/j.eurpsy.2022.2322 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Research Article
De la Peña-Arteaga, Víctor
Morgado, Pedro
Couto, Beatriz
Ferreira, Sónia
Castro, Inês
Sousa, Nuno
Soriano-Mas, Carles
Picó-Pérez, Maria
A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
title A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
title_full A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
title_fullStr A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
title_full_unstemmed A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
title_short A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
title_sort functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641649/
https://www.ncbi.nlm.nih.gov/pubmed/36184890
http://dx.doi.org/10.1192/j.eurpsy.2022.2322
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