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Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway

BACKGROUND: Asymptomatic COVID-19 cases have complicated the surveillance and tracking of the pandemic. Previous studies have estimated that 15–25% of all infectees remain asymptomatic. METHODS: Based on contact tracing data from Oslo, Norway, we estimated transmission and susceptibility dynamics am...

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Autores principales: Methi, Fredrik, Madslien, Elisabeth Henie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641677/
https://www.ncbi.nlm.nih.gov/pubmed/36348327
http://dx.doi.org/10.1186/s12916-022-02642-4
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author Methi, Fredrik
Madslien, Elisabeth Henie
author_facet Methi, Fredrik
Madslien, Elisabeth Henie
author_sort Methi, Fredrik
collection PubMed
description BACKGROUND: Asymptomatic COVID-19 cases have complicated the surveillance and tracking of the pandemic. Previous studies have estimated that 15–25% of all infectees remain asymptomatic. METHODS: Based on contact tracing data from Oslo, Norway, we estimated transmission and susceptibility dynamics among symptomatic and asymptomatic cases and their contacts as identified by manual contact tracing between September 1, 2020, and September 1, 2021. RESULTS: Among 27,473 indexes and 164,153 registered contacts, the secondary attack rate (SAR-14) was estimated to be 28% lower through asymptomatic exposure (13%) compared to symptomatic exposure (18%). Furthermore, those infected by asymptomatic cases were almost three times more likely to be asymptomatic compared to those infected by symptomatic cases. CONCLUSIONS: Symptomatic cases spread the virus to a greater extent than asymptomatic, and infectees are more likely to be asymptomatic if their assumed infector was asymptomatic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02642-4.
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spelling pubmed-96416772022-11-14 Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway Methi, Fredrik Madslien, Elisabeth Henie BMC Med Research Article BACKGROUND: Asymptomatic COVID-19 cases have complicated the surveillance and tracking of the pandemic. Previous studies have estimated that 15–25% of all infectees remain asymptomatic. METHODS: Based on contact tracing data from Oslo, Norway, we estimated transmission and susceptibility dynamics among symptomatic and asymptomatic cases and their contacts as identified by manual contact tracing between September 1, 2020, and September 1, 2021. RESULTS: Among 27,473 indexes and 164,153 registered contacts, the secondary attack rate (SAR-14) was estimated to be 28% lower through asymptomatic exposure (13%) compared to symptomatic exposure (18%). Furthermore, those infected by asymptomatic cases were almost three times more likely to be asymptomatic compared to those infected by symptomatic cases. CONCLUSIONS: Symptomatic cases spread the virus to a greater extent than asymptomatic, and infectees are more likely to be asymptomatic if their assumed infector was asymptomatic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02642-4. BioMed Central 2022-11-08 /pmc/articles/PMC9641677/ /pubmed/36348327 http://dx.doi.org/10.1186/s12916-022-02642-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Methi, Fredrik
Madslien, Elisabeth Henie
Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
title Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
title_full Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
title_fullStr Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
title_full_unstemmed Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
title_short Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
title_sort lower transmissibility of sars-cov-2 among asymptomatic cases: evidence from contact tracing data in oslo, norway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641677/
https://www.ncbi.nlm.nih.gov/pubmed/36348327
http://dx.doi.org/10.1186/s12916-022-02642-4
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