Cargando…
Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China
China has had explosive growth in ischemic stroke (IS) burden with significant ethnic and geographic disparities. The aim of this study was to explore the possible combination effect between gut microbiota and traditional potentially modifiable risk factors for IS among two ethnic minorities (Tujia...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641726/ https://www.ncbi.nlm.nih.gov/pubmed/36385753 http://dx.doi.org/10.3389/fnmol.2022.922399 |
_version_ | 1784826145302118400 |
---|---|
author | Zhang, Na Wang, Haoren Wang, Xiaolei Tian, Mengyuan Tian, Yong Li, Qi Liang, Chengcai Peng, Xiaowei Ding, Jian Wu, Xinrui Tan, Hongzhuan |
author_facet | Zhang, Na Wang, Haoren Wang, Xiaolei Tian, Mengyuan Tian, Yong Li, Qi Liang, Chengcai Peng, Xiaowei Ding, Jian Wu, Xinrui Tan, Hongzhuan |
author_sort | Zhang, Na |
collection | PubMed |
description | China has had explosive growth in ischemic stroke (IS) burden with significant ethnic and geographic disparities. The aim of this study was to explore the possible combination effect between gut microbiota and traditional potentially modifiable risk factors for IS among two ethnic minorities (Tujia and Miao) and the Han population. Herein, we first used the 16 S rRNA sequencing to compare the gut microbial compositions of 82 patients with first-ever IS vs. 82 normal controls (NCs) among Han, Tujia, and Miao people between 1 May 2018 and 30 April 2019, from Xiangxi Tujia and Miao Autonomous Prefecture in China. An additive model was used to study the interaction between traditional risk factors and gut microbiota with R software. Linear discriminant analysis (LDA) and LDA effect size (LEfSe) results showed that the identified key gut microbiota's taxonomic composition varied in different ethnicity between the IS patients and NCs. Furthermore, families Lactobacillaceae, Enterococcaceae, Streptococcaceae, and Enterobacteriaceae were found to be positively correlated with high-risk factors and negatively correlated with preventive factors in the IS patients, but families Ruminococcaceae and Lachnospiraceae were just the opposite in the NCs. There were additive interactions between traditional risk factors (systolic blood pressure, diastolic blood pressure, and high-sensitive C-reactive protein) and family Enterococcaceae for first-ever IS with the attributable proportion due to the interaction was 0.74, 0.71, and 0.85, respectively; and the synergy index was 4.45, 3.78, and 7.01, respectively. This preliminary but promising study showed that the gut microbiota disturbances may potentially interact to IS with different ethnic host's traditional risk factors. |
format | Online Article Text |
id | pubmed-9641726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96417262022-11-15 Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China Zhang, Na Wang, Haoren Wang, Xiaolei Tian, Mengyuan Tian, Yong Li, Qi Liang, Chengcai Peng, Xiaowei Ding, Jian Wu, Xinrui Tan, Hongzhuan Front Mol Neurosci Molecular Neuroscience China has had explosive growth in ischemic stroke (IS) burden with significant ethnic and geographic disparities. The aim of this study was to explore the possible combination effect between gut microbiota and traditional potentially modifiable risk factors for IS among two ethnic minorities (Tujia and Miao) and the Han population. Herein, we first used the 16 S rRNA sequencing to compare the gut microbial compositions of 82 patients with first-ever IS vs. 82 normal controls (NCs) among Han, Tujia, and Miao people between 1 May 2018 and 30 April 2019, from Xiangxi Tujia and Miao Autonomous Prefecture in China. An additive model was used to study the interaction between traditional risk factors and gut microbiota with R software. Linear discriminant analysis (LDA) and LDA effect size (LEfSe) results showed that the identified key gut microbiota's taxonomic composition varied in different ethnicity between the IS patients and NCs. Furthermore, families Lactobacillaceae, Enterococcaceae, Streptococcaceae, and Enterobacteriaceae were found to be positively correlated with high-risk factors and negatively correlated with preventive factors in the IS patients, but families Ruminococcaceae and Lachnospiraceae were just the opposite in the NCs. There were additive interactions between traditional risk factors (systolic blood pressure, diastolic blood pressure, and high-sensitive C-reactive protein) and family Enterococcaceae for first-ever IS with the attributable proportion due to the interaction was 0.74, 0.71, and 0.85, respectively; and the synergy index was 4.45, 3.78, and 7.01, respectively. This preliminary but promising study showed that the gut microbiota disturbances may potentially interact to IS with different ethnic host's traditional risk factors. Frontiers Media S.A. 2022-10-25 /pmc/articles/PMC9641726/ /pubmed/36385753 http://dx.doi.org/10.3389/fnmol.2022.922399 Text en Copyright © 2022 Zhang, Wang, Wang, Tian, Tian, Li, Liang, Peng, Ding, Wu and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Neuroscience Zhang, Na Wang, Haoren Wang, Xiaolei Tian, Mengyuan Tian, Yong Li, Qi Liang, Chengcai Peng, Xiaowei Ding, Jian Wu, Xinrui Tan, Hongzhuan Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China |
title | Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China |
title_full | Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China |
title_fullStr | Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China |
title_full_unstemmed | Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China |
title_short | Combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in Tujia, Miao and Han populations in China |
title_sort | combination effect between gut microbiota and traditional potentially modifiable risk factors for first-ever ischemic stroke in tujia, miao and han populations in china |
topic | Molecular Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641726/ https://www.ncbi.nlm.nih.gov/pubmed/36385753 http://dx.doi.org/10.3389/fnmol.2022.922399 |
work_keys_str_mv | AT zhangna combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT wanghaoren combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT wangxiaolei combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT tianmengyuan combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT tianyong combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT liqi combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT liangchengcai combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT pengxiaowei combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT dingjian combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT wuxinrui combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina AT tanhongzhuan combinationeffectbetweengutmicrobiotaandtraditionalpotentiallymodifiableriskfactorsforfirsteverischemicstrokeintujiamiaoandhanpopulationsinchina |