Cargando…

Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature

Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential...

Descripción completa

Detalles Bibliográficos
Autores principales: Więcek, Małgorzata, Gawlik, Jakub, Nowak, Zuzanna, Gawlik, Aneta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641775/
https://www.ncbi.nlm.nih.gov/pubmed/36191160
http://dx.doi.org/10.1530/EC-22-0344
_version_ 1784826155949359104
author Więcek, Małgorzata
Gawlik, Jakub
Nowak, Zuzanna
Gawlik, Aneta
author_facet Więcek, Małgorzata
Gawlik, Jakub
Nowak, Zuzanna
Gawlik, Aneta
author_sort Więcek, Małgorzata
collection PubMed
description Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential until they are ready to pursue procreation. One has to also remember about the additional risks connected with pregnancy in TS patients. In order to determine the optimal time for introducing FP techniques and decrease the chance of an unnecessary intervention, markers and procedures assessing ovarian reserve have been developed. The exposure to potential cardiovascular complications should be determined before FP to avoid unnecessary procedures in patients with potential contraindications to pregnancy. The aim of the present review is to answer the following three questions important for successful preservation of fertility and safe pregnancy in TS: which markers of ovarian reserve should be used as selection criteria for FP? Which methods of FP are the safest and most effective? Are there any cardiovascular contraindications to FP? For each of those questions, separate literature searches have been conducted. A total of 86 articles have been included in this review: 34 for the first question, 35 for the second, and 17 for the third. Ovarian reserve markers and cardiovascular contraindications to pregnancy should be established before FP; hoverer, there are no unambiguous indicators as to which patients should be disqualified from the FP and more evidence is needed in this subject.
format Online
Article
Text
id pubmed-9641775
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Bioscientifica Ltd
record_format MEDLINE/PubMed
spelling pubmed-96417752022-11-14 Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature Więcek, Małgorzata Gawlik, Jakub Nowak, Zuzanna Gawlik, Aneta Endocr Connect Review Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential until they are ready to pursue procreation. One has to also remember about the additional risks connected with pregnancy in TS patients. In order to determine the optimal time for introducing FP techniques and decrease the chance of an unnecessary intervention, markers and procedures assessing ovarian reserve have been developed. The exposure to potential cardiovascular complications should be determined before FP to avoid unnecessary procedures in patients with potential contraindications to pregnancy. The aim of the present review is to answer the following three questions important for successful preservation of fertility and safe pregnancy in TS: which markers of ovarian reserve should be used as selection criteria for FP? Which methods of FP are the safest and most effective? Are there any cardiovascular contraindications to FP? For each of those questions, separate literature searches have been conducted. A total of 86 articles have been included in this review: 34 for the first question, 35 for the second, and 17 for the third. Ovarian reserve markers and cardiovascular contraindications to pregnancy should be established before FP; hoverer, there are no unambiguous indicators as to which patients should be disqualified from the FP and more evidence is needed in this subject. Bioscientifica Ltd 2022-10-03 /pmc/articles/PMC9641775/ /pubmed/36191160 http://dx.doi.org/10.1530/EC-22-0344 Text en © The authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Więcek, Małgorzata
Gawlik, Jakub
Nowak, Zuzanna
Gawlik, Aneta
Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
title Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
title_full Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
title_fullStr Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
title_full_unstemmed Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
title_short Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
title_sort questions concerning fertility preservation during transition in girls with turner syndrome: review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641775/
https://www.ncbi.nlm.nih.gov/pubmed/36191160
http://dx.doi.org/10.1530/EC-22-0344
work_keys_str_mv AT wiecekmałgorzata questionsconcerningfertilitypreservationduringtransitioningirlswithturnersyndromereviewoftheliterature
AT gawlikjakub questionsconcerningfertilitypreservationduringtransitioningirlswithturnersyndromereviewoftheliterature
AT nowakzuzanna questionsconcerningfertilitypreservationduringtransitioningirlswithturnersyndromereviewoftheliterature
AT gawlikaneta questionsconcerningfertilitypreservationduringtransitioningirlswithturnersyndromereviewoftheliterature