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Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature
Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641775/ https://www.ncbi.nlm.nih.gov/pubmed/36191160 http://dx.doi.org/10.1530/EC-22-0344 |
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author | Więcek, Małgorzata Gawlik, Jakub Nowak, Zuzanna Gawlik, Aneta |
author_facet | Więcek, Małgorzata Gawlik, Jakub Nowak, Zuzanna Gawlik, Aneta |
author_sort | Więcek, Małgorzata |
collection | PubMed |
description | Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential until they are ready to pursue procreation. One has to also remember about the additional risks connected with pregnancy in TS patients. In order to determine the optimal time for introducing FP techniques and decrease the chance of an unnecessary intervention, markers and procedures assessing ovarian reserve have been developed. The exposure to potential cardiovascular complications should be determined before FP to avoid unnecessary procedures in patients with potential contraindications to pregnancy. The aim of the present review is to answer the following three questions important for successful preservation of fertility and safe pregnancy in TS: which markers of ovarian reserve should be used as selection criteria for FP? Which methods of FP are the safest and most effective? Are there any cardiovascular contraindications to FP? For each of those questions, separate literature searches have been conducted. A total of 86 articles have been included in this review: 34 for the first question, 35 for the second, and 17 for the third. Ovarian reserve markers and cardiovascular contraindications to pregnancy should be established before FP; hoverer, there are no unambiguous indicators as to which patients should be disqualified from the FP and more evidence is needed in this subject. |
format | Online Article Text |
id | pubmed-9641775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-96417752022-11-14 Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature Więcek, Małgorzata Gawlik, Jakub Nowak, Zuzanna Gawlik, Aneta Endocr Connect Review Loss of fertility is one of the most important concerns facing Turner syndrome (TS) patients as they transition into adult health care. Due to the limited and rapidly decreasing ovarian reserve, many TS patients require fertility preservation (FP) techniques to preserve their reproductive potential until they are ready to pursue procreation. One has to also remember about the additional risks connected with pregnancy in TS patients. In order to determine the optimal time for introducing FP techniques and decrease the chance of an unnecessary intervention, markers and procedures assessing ovarian reserve have been developed. The exposure to potential cardiovascular complications should be determined before FP to avoid unnecessary procedures in patients with potential contraindications to pregnancy. The aim of the present review is to answer the following three questions important for successful preservation of fertility and safe pregnancy in TS: which markers of ovarian reserve should be used as selection criteria for FP? Which methods of FP are the safest and most effective? Are there any cardiovascular contraindications to FP? For each of those questions, separate literature searches have been conducted. A total of 86 articles have been included in this review: 34 for the first question, 35 for the second, and 17 for the third. Ovarian reserve markers and cardiovascular contraindications to pregnancy should be established before FP; hoverer, there are no unambiguous indicators as to which patients should be disqualified from the FP and more evidence is needed in this subject. Bioscientifica Ltd 2022-10-03 /pmc/articles/PMC9641775/ /pubmed/36191160 http://dx.doi.org/10.1530/EC-22-0344 Text en © The authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Więcek, Małgorzata Gawlik, Jakub Nowak, Zuzanna Gawlik, Aneta Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature |
title | Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature |
title_full | Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature |
title_fullStr | Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature |
title_full_unstemmed | Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature |
title_short | Questions concerning fertility preservation during transition in girls with Turner syndrome: review of the literature |
title_sort | questions concerning fertility preservation during transition in girls with turner syndrome: review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641775/ https://www.ncbi.nlm.nih.gov/pubmed/36191160 http://dx.doi.org/10.1530/EC-22-0344 |
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