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Stressful experiences impact clinical symptoms in people with endometriosis

Endometriosis is a chronic condition that affects ~10% of women globally. Its symptoms include chronic pelvic pain, heavy periods and tiredness/fatigue, which have been associated with poorer quality of life and mental health. We aim to explore the impact of the COVID-19 pandemic on pain and fatigue...

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Autores principales: Demetriou, Lysia, Becker, Christian M, Martínez-Burgo, Beatriz, Invitti, Adriana L, Kvaskoff, Marina, Shah, Razneen, Evans, Emma, Lunde, Claire E, Cox, Emma, Garbutt, Kurtis, Zondervan, Krina T, Fox, Elaine, Vincent, Katy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641793/
http://dx.doi.org/10.1530/RAF-22-0028
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author Demetriou, Lysia
Becker, Christian M
Martínez-Burgo, Beatriz
Invitti, Adriana L
Kvaskoff, Marina
Shah, Razneen
Evans, Emma
Lunde, Claire E
Cox, Emma
Garbutt, Kurtis
Zondervan, Krina T
Fox, Elaine
Vincent, Katy
author_facet Demetriou, Lysia
Becker, Christian M
Martínez-Burgo, Beatriz
Invitti, Adriana L
Kvaskoff, Marina
Shah, Razneen
Evans, Emma
Lunde, Claire E
Cox, Emma
Garbutt, Kurtis
Zondervan, Krina T
Fox, Elaine
Vincent, Katy
author_sort Demetriou, Lysia
collection PubMed
description Endometriosis is a chronic condition that affects ~10% of women globally. Its symptoms include chronic pelvic pain, heavy periods and tiredness/fatigue, which have been associated with poorer quality of life and mental health. We aim to explore the impact of the COVID-19 pandemic on pain and fatigue symptoms and their interactions with the impact on mental health in people with endometriosis. This global cross-sectional online survey study collected data from 4717 adults with self-reported surgical/radiological diagnosis of endometriosis between May and June 2020. The survey included questions on the current status and changes of endometriosis symptoms (pelvic pain, tiredness/fatigue, and bleeding patterns), mental health, pain catastrophising, and the impact of the COVID-19 pandemic on the respondents’ lives. Compared to 6 months earlier, Respondents reported a marked worsening of their endometriosis symptoms (endometriosis-associated pain (39.3%; 95% CI: 37.7, 40.5), tiredness/fatigue (49.9%; 95% CI: 48.4, 51.2) and bleeding patterns (39.6%; 95% CI: 38.2, 41)) and mental health (38.6%; 95% CI: 37.2, 39.9). Those with a pre-existing mental health diagnosis (38.8%) were more likely to report their symptoms worsening. Worsening of pain and tiredness/fatigue was significantly correlated with worsening of mental health (P < 0.001). The relationship between changes in mental health and (a) change in pain and (b) change in fatigue was found to be weakly mediated by pain catastrophising scores (pain: B = 0.071, lower limit of confidence interval (LLCI) = 0.060, upper limit of confidence interval (ULCI) = 0.082, tiredness/fatigue: B = 0.050, LLCI = 0.040, ULCI = 0.060). This study demonstrates that stressful experiences impact the physical and mental health of people with endometriosis. The findings highlight the need to consider psychological approaches in the holistic management of people with endometriosis. LAY SUMMARY: Endometriosis is a chronic condition in which tissue similar to that of the lining of the womb grows outside it. It affects around 10% of women globally, and the symptoms often include persistent pelvic pain, heavy periods and tiredness/fatigue. These symptoms are associated with impaired mental health and life quality. This study used an online questionnaire to assess the experiences of people with endometriosis during the first months of the pandemic. Results from 4717 adults revealed that pelvic pain, tiredness/fatigue and bleeding worsened in more than 39% of the participants. Poor mental health was also exacerbated and associated with worsening in tiredness/fatigue. Further analysis revealed that this relationship could be partially explained by ‘pain catastrophising’, which measures how participants think about their pain. Our results suggest that stressful experiences like the pandemic negatively impact the already burdened mental health of people with endometriosis, who could benefit from psychological interventions.
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spelling pubmed-96417932022-11-14 Stressful experiences impact clinical symptoms in people with endometriosis Demetriou, Lysia Becker, Christian M Martínez-Burgo, Beatriz Invitti, Adriana L Kvaskoff, Marina Shah, Razneen Evans, Emma Lunde, Claire E Cox, Emma Garbutt, Kurtis Zondervan, Krina T Fox, Elaine Vincent, Katy Reprod Fertil Research Endometriosis is a chronic condition that affects ~10% of women globally. Its symptoms include chronic pelvic pain, heavy periods and tiredness/fatigue, which have been associated with poorer quality of life and mental health. We aim to explore the impact of the COVID-19 pandemic on pain and fatigue symptoms and their interactions with the impact on mental health in people with endometriosis. This global cross-sectional online survey study collected data from 4717 adults with self-reported surgical/radiological diagnosis of endometriosis between May and June 2020. The survey included questions on the current status and changes of endometriosis symptoms (pelvic pain, tiredness/fatigue, and bleeding patterns), mental health, pain catastrophising, and the impact of the COVID-19 pandemic on the respondents’ lives. Compared to 6 months earlier, Respondents reported a marked worsening of their endometriosis symptoms (endometriosis-associated pain (39.3%; 95% CI: 37.7, 40.5), tiredness/fatigue (49.9%; 95% CI: 48.4, 51.2) and bleeding patterns (39.6%; 95% CI: 38.2, 41)) and mental health (38.6%; 95% CI: 37.2, 39.9). Those with a pre-existing mental health diagnosis (38.8%) were more likely to report their symptoms worsening. Worsening of pain and tiredness/fatigue was significantly correlated with worsening of mental health (P < 0.001). The relationship between changes in mental health and (a) change in pain and (b) change in fatigue was found to be weakly mediated by pain catastrophising scores (pain: B = 0.071, lower limit of confidence interval (LLCI) = 0.060, upper limit of confidence interval (ULCI) = 0.082, tiredness/fatigue: B = 0.050, LLCI = 0.040, ULCI = 0.060). This study demonstrates that stressful experiences impact the physical and mental health of people with endometriosis. The findings highlight the need to consider psychological approaches in the holistic management of people with endometriosis. LAY SUMMARY: Endometriosis is a chronic condition in which tissue similar to that of the lining of the womb grows outside it. It affects around 10% of women globally, and the symptoms often include persistent pelvic pain, heavy periods and tiredness/fatigue. These symptoms are associated with impaired mental health and life quality. This study used an online questionnaire to assess the experiences of people with endometriosis during the first months of the pandemic. Results from 4717 adults revealed that pelvic pain, tiredness/fatigue and bleeding worsened in more than 39% of the participants. Poor mental health was also exacerbated and associated with worsening in tiredness/fatigue. Further analysis revealed that this relationship could be partially explained by ‘pain catastrophising’, which measures how participants think about their pain. Our results suggest that stressful experiences like the pandemic negatively impact the already burdened mental health of people with endometriosis, who could benefit from psychological interventions. Bioscientifica Ltd 2022-09-22 /pmc/articles/PMC9641793/ http://dx.doi.org/10.1530/RAF-22-0028 Text en © The authors https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research
Demetriou, Lysia
Becker, Christian M
Martínez-Burgo, Beatriz
Invitti, Adriana L
Kvaskoff, Marina
Shah, Razneen
Evans, Emma
Lunde, Claire E
Cox, Emma
Garbutt, Kurtis
Zondervan, Krina T
Fox, Elaine
Vincent, Katy
Stressful experiences impact clinical symptoms in people with endometriosis
title Stressful experiences impact clinical symptoms in people with endometriosis
title_full Stressful experiences impact clinical symptoms in people with endometriosis
title_fullStr Stressful experiences impact clinical symptoms in people with endometriosis
title_full_unstemmed Stressful experiences impact clinical symptoms in people with endometriosis
title_short Stressful experiences impact clinical symptoms in people with endometriosis
title_sort stressful experiences impact clinical symptoms in people with endometriosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641793/
http://dx.doi.org/10.1530/RAF-22-0028
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