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Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection

BACKGROUND: Endoscopic submucosal dissection (ESD) is becoming increasingly popular as a treatment for precancerous lesions and early cancers of the stomach. However, there have been few studies on the factors associated with the recurrence of precancerous lesions after ESD. METHODS: To investigate...

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Autores principales: Hong, Yongping, Chen, Xingxing, Li, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641826/
https://www.ncbi.nlm.nih.gov/pubmed/36344959
http://dx.doi.org/10.1186/s12893-022-01832-4
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author Hong, Yongping
Chen, Xingxing
Li, Guofeng
author_facet Hong, Yongping
Chen, Xingxing
Li, Guofeng
author_sort Hong, Yongping
collection PubMed
description BACKGROUND: Endoscopic submucosal dissection (ESD) is becoming increasingly popular as a treatment for precancerous lesions and early cancers of the stomach. However, there have been few studies on the factors associated with the recurrence of precancerous lesions after ESD. METHODS: To investigate the prognostic factors of gastric intraepithelial neoplasia, we retrospectively analyzed 115 patients who were treated with ESD between February 2018 and January 2020. Chi-square test and Fisher’s extract test were used to select factors for further investigation, and prognostic analysis was carried out with the Kaplan–Meier method and a Cox regression model. RESULTS: Platelet counts (P = 0.027) and albumin levels (P = 0.011) were both lower in patients with recurrence than in patients without recurrence of gastric mucosal atypical hyperplasia after ESD. CONCLUSIONS: This study reveals that low platelet counts and albumin levels were probably unfavorable prognostic factors in mucosal atypical hyperplasia of the stomach.
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spelling pubmed-96418262022-11-15 Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection Hong, Yongping Chen, Xingxing Li, Guofeng BMC Surg Research BACKGROUND: Endoscopic submucosal dissection (ESD) is becoming increasingly popular as a treatment for precancerous lesions and early cancers of the stomach. However, there have been few studies on the factors associated with the recurrence of precancerous lesions after ESD. METHODS: To investigate the prognostic factors of gastric intraepithelial neoplasia, we retrospectively analyzed 115 patients who were treated with ESD between February 2018 and January 2020. Chi-square test and Fisher’s extract test were used to select factors for further investigation, and prognostic analysis was carried out with the Kaplan–Meier method and a Cox regression model. RESULTS: Platelet counts (P = 0.027) and albumin levels (P = 0.011) were both lower in patients with recurrence than in patients without recurrence of gastric mucosal atypical hyperplasia after ESD. CONCLUSIONS: This study reveals that low platelet counts and albumin levels were probably unfavorable prognostic factors in mucosal atypical hyperplasia of the stomach. BioMed Central 2022-11-07 /pmc/articles/PMC9641826/ /pubmed/36344959 http://dx.doi.org/10.1186/s12893-022-01832-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hong, Yongping
Chen, Xingxing
Li, Guofeng
Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
title Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
title_full Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
title_fullStr Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
title_full_unstemmed Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
title_short Prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
title_sort prognostic factors in the treatment of gastric mucosal atypical hyperplasia by endoscopic submucosal dissection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641826/
https://www.ncbi.nlm.nih.gov/pubmed/36344959
http://dx.doi.org/10.1186/s12893-022-01832-4
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