Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis

BACKGROUND: Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (MS). Cladribine can cross the blood–brain barrier, suggest...

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Detalles Bibliográficos
Autores principales: Schroeter, Christina B., Rolfes, Leoni, Gothan, K. S. Sophie, Gruchot, Joel, Herrmann, Alexander M., Bock, Stefanie, Fazio, Luca, Henes, Antonia, Narayanan, Venu, Pfeuffer, Steffen, Nelke, Christopher, Räuber, Saskia, Huntemann, Niklas, Duarte-Silva, Eduardo, Dobelmann, Vera, Hundehege, Petra, Wiendl, Heinz, Raba, Katharina, Küry, Patrick, Kremer, David, Ruck, Tobias, Müntefering, Thomas, Budde, Thomas, Cerina, Manuela, Meuth, Sven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641831/
https://www.ncbi.nlm.nih.gov/pubmed/36348455
http://dx.doi.org/10.1186/s12974-022-02588-7

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