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Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) with associated microbleeds is a clinical entity presenting with cognitive impairment days or weeks after an episode of acute hypoxic brain injury. CASE REPORT: We describe a 68-year-old male with SARS-CoV2 infection who had cardiac arrest,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642034/ http://dx.doi.org/10.1016/j.nerep.2022.100150 |
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author | Garzón-Hernández, Jenny Paola Pabón-Moreno, Alexander Andrade-Rondón, Silvia Angélica Álvarez-Pabón, Yelitza Silva-Sieger, Federico Arturo |
author_facet | Garzón-Hernández, Jenny Paola Pabón-Moreno, Alexander Andrade-Rondón, Silvia Angélica Álvarez-Pabón, Yelitza Silva-Sieger, Federico Arturo |
author_sort | Garzón-Hernández, Jenny Paola |
collection | PubMed |
description | BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) with associated microbleeds is a clinical entity presenting with cognitive impairment days or weeks after an episode of acute hypoxic brain injury. CASE REPORT: We describe a 68-year-old male with SARS-CoV2 infection who had cardiac arrest, required sedation and mechanical ventilation for 17 days, and after sedation was discontinued, he became unresponsive. Brain MRI showed diffuse confluent hyperintense signals in the subcortical white matter and multiple subcortical white matter microhemorrhages. EEG revealed diffuse attenuation of brain electrical activity with isolated polymorphic delta waves in the frontal region without epileptiform activity. CONCLUSIONS: Clinicians need to be aware that patients with Covid-19 can develop delayed post-hypoxic leukoencephalopathy. |
format | Online Article Text |
id | pubmed-9642034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Authors. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96420342022-11-14 Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report Garzón-Hernández, Jenny Paola Pabón-Moreno, Alexander Andrade-Rondón, Silvia Angélica Álvarez-Pabón, Yelitza Silva-Sieger, Federico Arturo Neuroimmunology Reports Article BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) with associated microbleeds is a clinical entity presenting with cognitive impairment days or weeks after an episode of acute hypoxic brain injury. CASE REPORT: We describe a 68-year-old male with SARS-CoV2 infection who had cardiac arrest, required sedation and mechanical ventilation for 17 days, and after sedation was discontinued, he became unresponsive. Brain MRI showed diffuse confluent hyperintense signals in the subcortical white matter and multiple subcortical white matter microhemorrhages. EEG revealed diffuse attenuation of brain electrical activity with isolated polymorphic delta waves in the frontal region without epileptiform activity. CONCLUSIONS: Clinicians need to be aware that patients with Covid-19 can develop delayed post-hypoxic leukoencephalopathy. The Authors. Published by Elsevier B.V. 2022 2022-11-08 /pmc/articles/PMC9642034/ http://dx.doi.org/10.1016/j.nerep.2022.100150 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Garzón-Hernández, Jenny Paola Pabón-Moreno, Alexander Andrade-Rondón, Silvia Angélica Álvarez-Pabón, Yelitza Silva-Sieger, Federico Arturo Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report |
title | Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report |
title_full | Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report |
title_fullStr | Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report |
title_full_unstemmed | Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report |
title_short | Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report |
title_sort | covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – a case report |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642034/ http://dx.doi.org/10.1016/j.nerep.2022.100150 |
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