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Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report

BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) with associated microbleeds is a clinical entity presenting with cognitive impairment days or weeks after an episode of acute hypoxic brain injury. CASE REPORT: We describe a 68-year-old male with SARS-CoV2 infection who had cardiac arrest,...

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Autores principales: Garzón-Hernández, Jenny Paola, Pabón-Moreno, Alexander, Andrade-Rondón, Silvia Angélica, Álvarez-Pabón, Yelitza, Silva-Sieger, Federico Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642034/
http://dx.doi.org/10.1016/j.nerep.2022.100150
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author Garzón-Hernández, Jenny Paola
Pabón-Moreno, Alexander
Andrade-Rondón, Silvia Angélica
Álvarez-Pabón, Yelitza
Silva-Sieger, Federico Arturo
author_facet Garzón-Hernández, Jenny Paola
Pabón-Moreno, Alexander
Andrade-Rondón, Silvia Angélica
Álvarez-Pabón, Yelitza
Silva-Sieger, Federico Arturo
author_sort Garzón-Hernández, Jenny Paola
collection PubMed
description BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) with associated microbleeds is a clinical entity presenting with cognitive impairment days or weeks after an episode of acute hypoxic brain injury. CASE REPORT: We describe a 68-year-old male with SARS-CoV2 infection who had cardiac arrest, required sedation and mechanical ventilation for 17 days, and after sedation was discontinued, he became unresponsive. Brain MRI showed diffuse confluent hyperintense signals in the subcortical white matter and multiple subcortical white matter microhemorrhages. EEG revealed diffuse attenuation of brain electrical activity with isolated polymorphic delta waves in the frontal region without epileptiform activity. CONCLUSIONS: Clinicians need to be aware that patients with Covid-19 can develop delayed post-hypoxic leukoencephalopathy.
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spelling pubmed-96420342022-11-14 Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report Garzón-Hernández, Jenny Paola Pabón-Moreno, Alexander Andrade-Rondón, Silvia Angélica Álvarez-Pabón, Yelitza Silva-Sieger, Federico Arturo Neuroimmunology Reports Article BACKGROUND: Delayed post-hypoxic leukoencephalopathy (DPHL) with associated microbleeds is a clinical entity presenting with cognitive impairment days or weeks after an episode of acute hypoxic brain injury. CASE REPORT: We describe a 68-year-old male with SARS-CoV2 infection who had cardiac arrest, required sedation and mechanical ventilation for 17 days, and after sedation was discontinued, he became unresponsive. Brain MRI showed diffuse confluent hyperintense signals in the subcortical white matter and multiple subcortical white matter microhemorrhages. EEG revealed diffuse attenuation of brain electrical activity with isolated polymorphic delta waves in the frontal region without epileptiform activity. CONCLUSIONS: Clinicians need to be aware that patients with Covid-19 can develop delayed post-hypoxic leukoencephalopathy. The Authors. Published by Elsevier B.V. 2022 2022-11-08 /pmc/articles/PMC9642034/ http://dx.doi.org/10.1016/j.nerep.2022.100150 Text en © 2022 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Garzón-Hernández, Jenny Paola
Pabón-Moreno, Alexander
Andrade-Rondón, Silvia Angélica
Álvarez-Pabón, Yelitza
Silva-Sieger, Federico Arturo
Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
title Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
title_full Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
title_fullStr Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
title_full_unstemmed Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
title_short Covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – A case report
title_sort covid-19–associated diffuse posthypoxic leukoencephalopathy and microhemorrhages – a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642034/
http://dx.doi.org/10.1016/j.nerep.2022.100150
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