Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly defined. In this study, triggering an accumulation of ceramide in acute myeloid leukemia (AML) cells by inhibition of sphingosine kinase induced an apoptotic integrated st...

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Detalles Bibliográficos
Autores principales: Lewis, Alexander C., Pope, Victoria S., Tea, Melinda N., Li, Manjun, Nwosu, Gus O., Nguyen, Thao M., Wallington-Beddoe, Craig T., Moretti, Paul A. B., Anderson, Dovile, Creek, Darren J., Costabile, Maurizio, Ali, Saira R., Thompson-Peach, Chloe A. L., Dredge, B. Kate, Bert, Andrew G., Goodall, Gregory J., Ekert, Paul G., Brown, Anna L., D’Andrea, Richard, Robinson, Nirmal, Pitman, Melissa R., Thomas, Daniel, Ross, David M., Gliddon, Briony L., Powell, Jason A., Pitson, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642852/
https://www.ncbi.nlm.nih.gov/pubmed/35443029
http://dx.doi.org/10.1182/blood.2021013277

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