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Potentiating effect of reovirus on immune checkpoint inhibition in microsatellite stable colorectal cancer

The majority of colorectal cancers (CRCs) are microsatellite stable (MSS) and resistant to immunotherapy. The current study explores the possibility of using oncolytic reovirus to sensitize MSS CRC to immune checkpoint inhibition. While reovirus reduced metabolic activity among KRAS (Mut) cells, mic...

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Detalles Bibliográficos
Autores principales:	Augustine, Titto, John, Peter, Friedman, Tyler, Jiffry, Jeeshan, Guzik, Hillary, Mannan, Rifat, Gupta, Riya, Delano, Catherine, Mariadason, John M., Zang, Xingxing, Maitra, Radhashree, Goel, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642964/ https://www.ncbi.nlm.nih.gov/pubmed/36387154 http://dx.doi.org/10.3389/fonc.2022.1018767

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