Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

Trained immunity is an innate immune memory response that is induced by a primary inflammatory stimulus that sensitizes monocytes and macrophages to a secondary pathogenic challenge, reprogramming the host response to infection and inflammatory disease. Dietary fatty acids can act as inflammatory st...

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Detalles Bibliográficos
Autores principales: Seufert, Amy L, Hickman, James W, Traxler, Ste K, Peterson, Rachael M, Waugh, Trent A, Lashley, Sydney J, Shulzhenko, Natalia, Napier, Ruth J, Napier, Brooke A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642993/
https://www.ncbi.nlm.nih.gov/pubmed/36264059
http://dx.doi.org/10.7554/eLife.76744

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