A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene

Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish (Danio rerio) that could be used to facilitate novel functional genome annotation towards understanding molecular underpinnings of human diseases (Ichino et al, 2020). Here, we report...

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Detalles Bibliográficos
Autores principales: Ding, Yonghe, Lang, Di, Yan, Jianhua, Bu, Haisong, Li, Hongsong, Jiao, Kunli, Yang, Jingchun, Ni, Haibo, Morotti, Stefano, Le, Tai, Clark, Karl J, Port, Jenna, Ekker, Stephen C, Cao, Hung, Zhang, Yuji, Wang, Jun, Grandi, Eleonora, Li, Zhiqiang, Shi, Yongyong, Li, Yigang, Glukhov, Alexey V, Xu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9642998/
https://www.ncbi.nlm.nih.gov/pubmed/36255053
http://dx.doi.org/10.7554/eLife.77327

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