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New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Natural products, and especially the active ingredients found in traditional Chinese medicine (TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such, traditional remedies provide shortcuts for the development of original new drugs in China, and increa...

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Autores principales: Zhu, Yuyu, Ouyang, Zijun, Du, Haojie, Wang, Meijing, Wang, Jiaojiao, Sun, Haiyan, Kong, Lingdong, Xu, Qiang, Ma, Hongyue, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643300/
https://www.ncbi.nlm.nih.gov/pubmed/36386472
http://dx.doi.org/10.1016/j.apsb.2022.08.022
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author Zhu, Yuyu
Ouyang, Zijun
Du, Haojie
Wang, Meijing
Wang, Jiaojiao
Sun, Haiyan
Kong, Lingdong
Xu, Qiang
Ma, Hongyue
Sun, Yang
author_facet Zhu, Yuyu
Ouyang, Zijun
Du, Haojie
Wang, Meijing
Wang, Jiaojiao
Sun, Haiyan
Kong, Lingdong
Xu, Qiang
Ma, Hongyue
Sun, Yang
author_sort Zhu, Yuyu
collection PubMed
description Natural products, and especially the active ingredients found in traditional Chinese medicine (TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such, traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and single-cell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization.
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spelling pubmed-96433002022-11-15 New opportunities and challenges of natural products research: When target identification meets single-cell multiomics Zhu, Yuyu Ouyang, Zijun Du, Haojie Wang, Meijing Wang, Jiaojiao Sun, Haiyan Kong, Lingdong Xu, Qiang Ma, Hongyue Sun, Yang Acta Pharm Sin B Review Natural products, and especially the active ingredients found in traditional Chinese medicine (TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such, traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and single-cell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization. Elsevier 2022-11 2022-08-27 /pmc/articles/PMC9643300/ /pubmed/36386472 http://dx.doi.org/10.1016/j.apsb.2022.08.022 Text en © 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Zhu, Yuyu
Ouyang, Zijun
Du, Haojie
Wang, Meijing
Wang, Jiaojiao
Sun, Haiyan
Kong, Lingdong
Xu, Qiang
Ma, Hongyue
Sun, Yang
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
title New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
title_full New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
title_fullStr New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
title_full_unstemmed New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
title_short New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
title_sort new opportunities and challenges of natural products research: when target identification meets single-cell multiomics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643300/
https://www.ncbi.nlm.nih.gov/pubmed/36386472
http://dx.doi.org/10.1016/j.apsb.2022.08.022
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