Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Although the effective drugs or vaccines have been developed to prevent the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), their efficacy may be limited for the viral evolution and immune escape. Thus, it is urgently needed to develop the novel broad-spectrum antiviral a...

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Detalles Bibliográficos
Autores principales: Wang, Ruyu, Zhai, Guanglei, Zhu, Guanghao, Wang, Mengge, Gong, Xiaoyi, Zhang, Weidong, Ge, Guangbo, Chen, Hongzhuan, Chen, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643332/
https://www.ncbi.nlm.nih.gov/pubmed/36395603
http://dx.doi.org/10.1016/j.bioorg.2022.106264

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