Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice

Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian rhythm and the relation of such a decrease with apoptosis. Here, we discovered a molecule (M47) that destabilizes Crypto...

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Detalles Bibliográficos
Autores principales: Gul, Seref, Akyel, Yasemin Kubra, Gul, Zeynep Melis, Isin, Safak, Ozcan, Onur, Korkmaz, Tuba, Selvi, Saba, Danis, Ibrahim, Ipek, Ozgecan Savlug, Aygenli, Fatih, Taskin, Ali Cihan, Akarlar, Büşra Aytül, Ozlu, Nurhan, Ozturk, Nuri, Ozturk, Narin, Ünal, Durişehvar Özer, Guzel, Mustafa, Turkay, Metin, Okyar, Alper, Kavakli, Ibrahim Halil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643396/
https://www.ncbi.nlm.nih.gov/pubmed/36347873
http://dx.doi.org/10.1038/s41467-022-34582-1

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