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Pharmacokinetics and efficacy of topical inserts containing tenofovir alafenamide fumarate and elvitegravir administered rectally in macaques

BACKGROUND: Topical on-demand forms for HIV pre-exposure prophylaxis (PrEP) may be a desirable alternative for people that prefer not to use daily PrEP. CONRAD has developed inserts containing tenofovir alafenamide (TAF) and elvitegravir (EVG) for on-demand vaginal or rectal pericoital use. We asses...

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Detalles Bibliográficos
Autores principales:	Makarova, Natalia, Singletary, Tyana, Peet, M. Melissa, Mitchell, James, Holder, Angela, Dinh, Chuong, Agrahari, Vivek, Mendoza, Maria, Pan, Yi, Heneine, Walid, Clark, Meredith R., García-Lerma, J. Gerardo, Smith, James M., Doncel, Gustavo F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643401/ https://www.ncbi.nlm.nih.gov/pubmed/36343572 http://dx.doi.org/10.1016/j.ebiom.2022.104338

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