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Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study

BACKGROUND: Neoadjuvant chemotherapy (NAC) could improve local tumor control of locally advanced colon cancer (LACC), but the prognostic value of yp stage in colon cancer remains unknown. Here, we aimed to ascertain yp stage as an indicator for LACC prognosis after NAC. METHODS: The data of patients...

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Autores principales: Xiang, Meijuan, Liang, Zongyu, Gao, Yuan, Feng, Xingyu, Yao, Xueqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643450/
https://www.ncbi.nlm.nih.gov/pubmed/36386548
http://dx.doi.org/10.3389/fsurg.2022.1022025
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author Xiang, Meijuan
Liang, Zongyu
Gao, Yuan
Feng, Xingyu
Yao, Xueqing
author_facet Xiang, Meijuan
Liang, Zongyu
Gao, Yuan
Feng, Xingyu
Yao, Xueqing
author_sort Xiang, Meijuan
collection PubMed
description BACKGROUND: Neoadjuvant chemotherapy (NAC) could improve local tumor control of locally advanced colon cancer (LACC), but the prognostic value of yp stage in colon cancer remains unknown. Here, we aimed to ascertain yp stage as an indicator for LACC prognosis after NAC. METHODS: The data of patients diagnosed with colon adenocarcinoma between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results database. After 1:2 propensity score matching, cancer-specific survival (CSS) and overall survival (OS) were compared between the NAC and Non-NAC groups of different stage classifications. The correlation between clinical and pathological factors and CSS was identified. RESULTS: A total of 49, 149, and 81 matched pairs of stage 0–I, II, and III patients, respectively, were generated for analysis. For stage 0–I (p = 0.011) and III (p = 0.015), only CSS in the NAC groups were inferior. Receiving NAC was an independent prognostic risk factor for patients with stage 0–I (hazard ratio, 7.70; 95% confidence interval, 1.820–32.5; p = 0.006) and stage III (hazard ratio, 1.73; 95% confidence interval, 1.11–2.68; p = 0.015). CONCLUSIONS: The CSS was poorer among LACC patients who underwent NAC than among those who did not. The yp stage of colon cancer after NAC has distinctive significance, which may contribute to predicting the prognosis and guiding the treatment of LACC patients after NAC.
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spelling pubmed-96434502022-11-15 Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study Xiang, Meijuan Liang, Zongyu Gao, Yuan Feng, Xingyu Yao, Xueqing Front Surg Surgery BACKGROUND: Neoadjuvant chemotherapy (NAC) could improve local tumor control of locally advanced colon cancer (LACC), but the prognostic value of yp stage in colon cancer remains unknown. Here, we aimed to ascertain yp stage as an indicator for LACC prognosis after NAC. METHODS: The data of patients diagnosed with colon adenocarcinoma between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results database. After 1:2 propensity score matching, cancer-specific survival (CSS) and overall survival (OS) were compared between the NAC and Non-NAC groups of different stage classifications. The correlation between clinical and pathological factors and CSS was identified. RESULTS: A total of 49, 149, and 81 matched pairs of stage 0–I, II, and III patients, respectively, were generated for analysis. For stage 0–I (p = 0.011) and III (p = 0.015), only CSS in the NAC groups were inferior. Receiving NAC was an independent prognostic risk factor for patients with stage 0–I (hazard ratio, 7.70; 95% confidence interval, 1.820–32.5; p = 0.006) and stage III (hazard ratio, 1.73; 95% confidence interval, 1.11–2.68; p = 0.015). CONCLUSIONS: The CSS was poorer among LACC patients who underwent NAC than among those who did not. The yp stage of colon cancer after NAC has distinctive significance, which may contribute to predicting the prognosis and guiding the treatment of LACC patients after NAC. Frontiers Media S.A. 2022-10-26 /pmc/articles/PMC9643450/ /pubmed/36386548 http://dx.doi.org/10.3389/fsurg.2022.1022025 Text en © 2022 Xiang, Liang, Gao, Feng and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Xiang, Meijuan
Liang, Zongyu
Gao, Yuan
Feng, Xingyu
Yao, Xueqing
Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
title Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
title_full Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
title_fullStr Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
title_full_unstemmed Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
title_short Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
title_sort prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: a propensity score-matched study
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643450/
https://www.ncbi.nlm.nih.gov/pubmed/36386548
http://dx.doi.org/10.3389/fsurg.2022.1022025
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